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β-Thalassaemia : emergence of new and improved iron chelators for treatment

Wong, Cynthia and Richardson, Des R. 2003, β-Thalassaemia : emergence of new and improved iron chelators for treatment, The international journal of biochemistry & cell biology, vol. 35, no. 7, pp. 1144-1149, doi: 10.1016/S1357-2725(03)00046-3.

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Title β-Thalassaemia : emergence of new and improved iron chelators for treatment
Author(s) Wong, Cynthia
Richardson, Des R.
Journal name The international journal of biochemistry & cell biology
Volume number 35
Issue number 7
Start page 1144
End page 1149
Publisher Elsevier
Place of publication New York, N. Y.
Publication date 2003-07
ISSN 1357-2725
Summary β-Thalassaemia is an inherited blood disorder which through repeated blood transfusions and enhanced iron uptake from the gastrointestinal tract, results in marked iron overload. Untreated, the iron accumulation results in the dysfunction of vital organs such as the heart and liver. At present, the most effective treatment for β-thalassaemia is the use of the iron chelator, desferrioxamine, which is expensive, orally inactive and requires long subcutaneous infusions. In this concise review, we will focus on novel chelators which show therapeutic potential to replace desferrioxamine. Furthermore, we will discuss the potential of combined iron chelation therapy and the principle that, in the future, the use of more than just one chelator may be beneficial in tailoring individual iron chelation regimens.
Language eng
DOI 10.1016/S1357-2725(03)00046-3
Field of Research 110103 Medical Biochemistry: Inorganic Elements and Compounds
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2003, Elsevier Science Ltd.
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Document type: Journal Article
Collection: Centre for Material and Fibre Innovation
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Created: Fri, 26 Mar 2010, 13:38:07 EST

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