Grafts in myringoplasty : utilizing a silk fibroin scaffold as a novel device

Levin, Brett, Rajkhowa, Rangam, Redmond, Sharon Leanne and Atlas, Marcus David 2009, Grafts in myringoplasty : utilizing a silk fibroin scaffold as a novel device, Expert review of medical devices, vol. 6, no. 6, pp. 653-664.

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Title Grafts in myringoplasty : utilizing a silk fibroin scaffold as a novel device
Author(s) Levin, Brett
Rajkhowa, Rangam
Redmond, Sharon Leanne
Atlas, Marcus David
Journal name Expert review of medical devices
Volume number 6
Issue number 6
Start page 653
End page 664
Total pages 12
Publisher Expert Reviews Ltd.
Place of publication London, England
Publication date 2009
ISSN 1743-4440
1745-2422
Keyword(s) biomaterial
fibroin
graft
myringoplasty
perforation
silk
tissue engineering
tympanic membrane
Summary Chronic perforations of the eardrum or tympanic membrane represent a significant source of morbidity worldwide. Myringoplasty is the operative repair of a perforated tympanic membrane and is a procedure commonly performed by otolaryngologists. Its purpose is to close the tympanic membrane, improve hearing and limit patient susceptibility to middle ear infections. The success rates of the different surgical techniques used to perform a myringoplasty, and the optimal graft materials to achieve complete closure and restore hearing, vary significantly in the literature. A number of autologous tissues, homografts and synthetic materials are described as graft options. With the advent and development of tissue engineering in the last decade, a number of biomaterials have been studied and attempts have been made to mimic biological functions with these materials. Fibroin, a core structural protein in silk from silkworms, has been widely studied with biomedical applications in mind. Several cell types, including keratinocytes, have grown on silk biomaterials, and scaffolds manufactured from silk have successfully been used in wound healing and for tissue engineering purposes. This review focuses on the current available grafts for myringoplasty and their limitations, and examines the biomechanical properties of silk, assessing the potential benefits of a silk fibroin scaffold as a novel device for use as a graft in myringoplasty surgery.
Language eng
Field of Research 100708 Nanomaterials
Socio Economic Objective 869999 Manufacturing not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2009
Copyright notice ©2009, Expert Reviews
Persistent URL http://hdl.handle.net/10536/DRO/DU:30026178

Document type: Journal Article
Collection: Centre for Material and Fibre Innovation
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