Porous TiNbZr alloy scaffolds for biomedical applications

Wang, Xiaojian, Li, Yuncang, Xiong, Jianyu, Hodgson, Peter D. and Wen, Cui'e 2009, Porous TiNbZr alloy scaffolds for biomedical applications, Acta biomaterialia, vol. 5, no. 9, pp. 3616-3624, doi: 10.1016/j.actbio.2009.06.002.

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Title Porous TiNbZr alloy scaffolds for biomedical applications
Author(s) Wang, Xiaojian
Li, Yuncang
Xiong, Jianyu
Hodgson, Peter D.
Wen, Cui'e
Journal name Acta biomaterialia
Volume number 5
Issue number 9
Start page 3616
End page 3624
Total pages 9
Publisher Elsevier BV
Place of publication Amsterdam, Netherlands
Publication date 2009-11
ISSN 1742-7061
1878-7568
Keyword(s) Titanium alloy
Scaffold
Mechanical properties
Biocompatibility
Summary In the present study, porous Ti–10Nb–10Zr alloy scaffolds with different porosities were successfully fabricated by a ‘‘space-holder” sintering method. By the addition of biocompatible alloying elements the porous TiNbZr scaffolds achieved significantly higher strength than unalloyed Ti scaffolds of the same porosity. In particular, the porous TiNbZr alloy with 59% porosity exhibited an elastic modulus and plateau stress of 5.6 GPa and 137 MPa, respectively. The porous alloys exhibited excellent ductility during compression tests and the deformation mechanism is mainly governed by bending and buckling of the struts. Cell cultures revealed that SaOS2 osteoblast-like cells grew on the surface and inside the pores and showed good spreading. Cell viability for the porous scaffold was three times higher than the solid counterpart. The present study has demonstrated that the porous TiNbZr alloy scaffolds are promising scaffold biomaterials for
bone tissue engineering by virtue of their appropriate mechanical properties, highly porous structure and excellent biocompatibility.
Language eng
DOI 10.1016/j.actbio.2009.06.002
Field of Research 091207 Metals and Alloy Materials
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2009, Elsevier Ltd.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30026211

Document type: Journal Article
Collections: Centre for Material and Fibre Innovation
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