Recent advances on the roles of NO in cancer and chronic inflammatory disorders

Kanwar, Jagat R., Kanwar, Rupinder K., Burrow, Hannah and Baratchi, Sara 2009, Recent advances on the roles of NO in cancer and chronic inflammatory disorders, Current medicinal chemistry, vol. 16, no. 19, pp. 2373-2394.


Title Recent advances on the roles of NO in cancer and chronic inflammatory disorders
Author(s) Kanwar, Jagat R.
Kanwar, Rupinder K.
Burrow, Hannah
Baratchi, Sara
Journal name Current medicinal chemistry
Volume number 16
Issue number 19
Start page 2373
End page 2394
Total pages 18
Publisher Bentham Science
Place of publication Bussum, Netherlands
Publication date 2009-07
ISSN 0929-8673
1875-533X
Keyword(s) inflammation etiology
neoplasms etiology
nitric oxide physiology
Summary Nitric oxide (NO) is a short-life molecule produced by the enzyme known as the nitric oxide synthase (NOS), in a reaction that converts arginine and oxygen into citrulline and NO. There are three isoforms of the enzyme: neuronal NOS (nNOS, also called NOS1), inducible NOS (iNOS or NOS2), and endothelial NOS (eNOS or NOS3). It is now known that each of these isoforms may be expressed in a variety of tissues and cell types. This paper is a review of the current knowledge of various functions of NO in diseases. We discuss in more detail its role in Cancer, the role of NO in myocardial pathophysiology, in central nervous system (CNS) pathologies. Other diseases such as inflammation, asthma, in chronic liver diseases, inflammatory bowel disease (IBD), arthritis, are also discussed. This review also covers the role of NO in cardiovascular, central nervous, pancreas, lung, gut, kidney, myoskeletal and chronic liver diseases (CLD). The ubiquitous role that the simple gas nitric oxide plays in the body, from maintaining vascular homeostasis and fighting infections to acting as a neurotransmitter and its role in cancer, has spurred a lot of interest among researchers all over the world. Nitric oxide plays an important role in the physiologic modulation of coronary artery tone and myocardial function. Nitric oxide from iNOS appears to be a key mediator of such glial-induced neuronal death. The high sensitivity of neurons to NO is partly due to NO causing inhibition of respiration, rapid glutamate release from both astrocytes and neurons, and subsequent excitotoxic death of the neurons.
Language eng
Field of Research 030401 Biologically Active Molecules
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30026294

Document type: Journal Article
Collection: Centre for Biotechnology and Interdisciplinary Sciences (BioDeakin)
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Created: Tue, 30 Mar 2010, 12:47:56 EST by Rupinder Kanwar

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