Recent advances of metal binding protein lactoferrin as an anti-microbial agent

Gupta, Isha, Sehgal, Rakesh, Kanwar, Rupinder K., Sehgal, Alka and Kanwar, Jagat R. 2009, Recent advances of metal binding protein lactoferrin as an anti-microbial agent, Current bioactive compounds, vol. 5, no. 3, pp. 226-233.

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Title Recent advances of metal binding protein lactoferrin as an anti-microbial agent
Author(s) Gupta, Isha
Sehgal, Rakesh
Kanwar, Rupinder K.
Sehgal, Alka
Kanwar, Jagat R.
Journal name Current bioactive compounds
Volume number 5
Issue number 3
Start page 226
End page 233
Total pages 8
Publisher Bentham Science
Place of publication Bussum, Netherlands
Publication date 2009-09
ISSN 1573-4072
1875-6646
Summary Lactoferrin (Lf) is present in milk and gland secretions and serve as an antimicrobial function. Insufficient amounts of Lf in some secretions also appear to correlate with certain health problems. Protection against gastroenteritis is the most likely biologically relevant activity of lactoferrin. Multiple in vitro and animal studies have shown a protective effect of lactoferrin on infections with enteric microorganisms, including rotavirus, Giardia, Shigella, Salmonella and the diarrheagenic Escherichia coli. Lactoferrin has two major effects on enteric pathogens: it inhibits growth and it impairs function of surface expressed virulence factors thereby decreasing their ability to adhere or to invade mammalian cells. Lf also inhibits several species of fungi and certain parasites. This review covers the role of Lf in clearing the parasitic infections. The mechanism by which lactoferrin inhibits some parasites may be via stimulation of the process of phagocytosis, whereby immune cells engulf and digest foreign organisms. Trichomonas vaginalis is a protozoan responsible for the number one, non-viral sexually transmitted disease. In this review, we also discussed the role of Lf in cervical infections.
Language eng
Field of Research 110803 Medical Parasitology
110801 Medical Bacteriology
110899 Medical Microbiology not elsewhere classified
Socio Economic Objective 920109 Infectious Diseases
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2009, Bentham Science
Persistent URL http://hdl.handle.net/10536/DRO/DU:30026298

Document type: Journal Article
Collection: Centre for Biotechnology and Interdisciplinary Sciences (BioDeakin)
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Created: Tue, 30 Mar 2010, 13:22:30 EST by Rupinder Kanwar

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