Anti-inflammatory immunotherapy for multiple sclerosis/experimental autoimmune encephalomyelitis (EAE) disease

Kanwar, Jagat R. 2005, Anti-inflammatory immunotherapy for multiple sclerosis/experimental autoimmune encephalomyelitis (EAE) disease, Current medicinal chemistry, vol. 12, no. 25, pp. 2947-2962.

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Title Anti-inflammatory immunotherapy for multiple sclerosis/experimental autoimmune encephalomyelitis (EAE) disease
Author(s) Kanwar, Jagat R.
Journal name Current medicinal chemistry
Volume number 12
Issue number 25
Start page 2947
End page 2962
Total pages 12
Publisher Bentham Science
Place of publication Bussum, Netherlands
Publication date 2005
ISSN 0929-8673
1875-533X
Keyword(s) cell adhesion molecules
immunotherapy
oligodendrocytes
neuroprotection
neurons
cytokine
demyelination
multiple sclerosis
experimental autoimmune encephalomyelitis
Summary Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are inflammatory diseases of the central nervous system (CNS) characterized by localized areas with demyelination. Disease is believed to be an autoimmune disorder mediated by activated immune cells such as T- and B-lymphocytes and macrophages/microglia. Lymphocytes are primed in the peripheral tissues by antigens, and clonally expanded cells infiltrate the CNS. They produce large amounts of inflammatory cytokines, nitric oxide (NO) that lead to demyelination and axonal degeneration. Although several studies have shown that oligodendrocytes (OLGs), the myelin-forming glial cells in the CNS, are sensitive to cell death stimuli, such as cytotoxic cytokines, anti-myelin antibodies, NO, and oxidative stress, in vitro, the mechanisms underlying injury to the OLGs in MS/EAE remain unclear. The central role of glutamate receptors in mediating excitotoxic neuronal death in stroke, epilepsy, trauma and MS has been well established. Glutamate is the major excitatory amino acid transmitter within the CNS and it's signaling is mediated by a number of postsynaptic ionotropic and metabotropic receptors. Inflammation can be blocked with anti-cell adhesion molecules MAb, simultaneously protected oligodendrocytes and neurons against glutamate-mediated damage with the AMPA/kainate antagonist NBQX, and the NMDA receptor antagonist GPE, could thus be effective therapies for multiple sclerosis.
Language eng
Field of Research 110904 Neurology and Neuromuscular Diseases
110702 Applied Immunology (incl Antibody Engineering, Xenotransplantation and T-cell Therapies)
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2005, Bentham Science Publishers Ltd.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30026567

Document type: Journal Article
Collection: Institute of Biotechnology
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Created: Thu, 01 Apr 2010, 11:08:28 EST by Jagat Kanwar

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