Mouse B7-H3 induces antitumor immunity

Sun, X., Vale, M., Leung, E., Kanwar, J.R., Gupta, R. and Krissansen, G.W. 2003, Mouse B7-H3 induces antitumor immunity, Gene therapy, vol. 10, no. 20, pp. 1728-1734.


Title Mouse B7-H3 induces antitumor immunity
Author(s) Sun, X.
Vale, M.
Leung, E.
Kanwar, J.R.
Gupta, R.
Krissansen, G.W.
Journal name Gene therapy
Volume number 10
Issue number 20
Start page 1728
End page 1734
Publisher Nature Publishing Group
Place of publication London, England
Publication date 2003-09
ISSN 0969-7128
1476-5462
Summary Members of the B7 family costimulate the proliferation of lymphocytes during the initiation and maintenance of antigen-specific humoral and cell-mediated immune responses. While B7-1 and -2 are restricted to lymphoid tissues, and activate naïve T cells, recently identified members including B7-H2 and -H3 are widely expressed on nonlymphoid tissues, and regulate effector lymphocytes in the periphery. B7-H3 has properties that suggested it may display antitumor activity, including the ability to stimulate Th1 and cytotoxic T-cell responses. Here, we test this notion by determining whether intratumoral injection of an expression plasmid encoding a newly described mouse homologue of B7-H3 is able to eradicate EL-4 lymphomas. Intratumoral injection of a mouse B7-H3 pcDNA3 expression plasmid led to complete regression of 50% tumors, or otherwise significantly slowed tumor growth. Mice whose tumors completely regressed resisted a challenge with parental tumor cells, indicating systemic immunity had been generated. B7-H3-mediated antitumor immunity was mediated by CD8(+) T and NK cells, with no apparent contribution from CD4(+) T cells. In summary, the results indicate that B7-H3 interactions may play a role in regulating cell-mediated immune responses against cancer, and that B7-H3 is a potential therapeutic tool.
Language eng
Field of Research 110702 Applied Immunology (incl Antibody Engineering, Xenotransplantation and T-cell Therapies)
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2003, Nature Publishing Group
Persistent URL http://hdl.handle.net/10536/DRO/DU:30026568

Document type: Journal Article
Collection: Institute for Technology Research and Innovation
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Created: Thu, 01 Apr 2010, 11:30:34 EST by Jagat Kanwar

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