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Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells

Cheung, Chun Hei Antonio, Chen, Huang-Hui, Cheng, Li-Ting, Lyu, Kevin W., Kanwar, Jagat R. and Chang, Jang-Yang 2010, Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells, Molecular cancer, vol. 9, no. 77, pp. 1-11.

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Title Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells
Author(s) Cheung, Chun Hei Antonio
Chen, Huang-Hui
Cheng, Li-Ting
Lyu, Kevin W.
Kanwar, Jagat R.
Chang, Jang-Yang
Journal name Molecular cancer
Volume number 9
Issue number 77
Start page 1
End page 11
Publisher BioMed Central
Place of publication London, England
Publication date 2010-04
ISSN 1476-4598
Summary Survivin is a dual functioning protein. It inhibits the apoptosis of cancer cells by inhibiting caspases, and also promotes cancer cell growth by stabilizing microtubules during mitosis. Since the molecular chaperone Hsp90 binds and stabilizes survivin, it is widely believed that down-regulation of survivin is one of the important therapeutic functions of Hsp90 inhibitors such as the phase III clinically trialed compound 17-AAG. However, Hsp90 interferes with a number of molecules that up-regulate the intracellular level of survivin, raising the question that clinical use of Hsp90 inhibitors may indirectly induce survivin expression and subsequently enhance cancer anti-drug responses. The purpose of this study is to determine whether targeting Hsp90 can alter survivin expression differently in different cancer cell lines and to explore possible mechanisms that cause the alteration in survivin expression.
Notes This is an open access article distributed under the terms of the attached BioMed Central License. See license for details.
Language eng
Field of Research 111201 Cancer Cell Biology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2010, Cheung et al.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30026574

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Created: Thu, 01 Apr 2010, 14:17:14 EST by Jagat Kanwar