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Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells Cheung, Chun Hei Antonio, Chen, Huang-Hui, Cheng, Li-Ting, Lyu, Kevin W., Kanwar, Jagat R. and Chang, Jang-Yang 2010, Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells, Molecular cancer, vol. 9, no. 77, pp. 1-11. Attached Files Name Description MIMEType Size Downloads kanwar-targetinghsp90-2010.pdf Published version application/pdf 1.50MB 73 Title Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells Author(s) Cheung, Chun Hei Antonio Chen, Huang-Hui Cheng, Li-Ting Lyu, Kevin W. Kanwar, Jagat R. Chang, Jang-Yang Journal name Molecular cancer Volume number 9 Issue number 77 Start page 1 End page 11 Total pages 11 Publisher BioMed Central Place of publication London, England Publication date 2010-04 ISSN 1476-4598 Summary Survivin is a dual functioning protein. It inhibits the apoptosis of cancer cells by inhibiting caspases, and also promotes cancer cell growth by stabilizing microtubules during mitosis. Since the molecular chaperone Hsp90 binds and stabilizes survivin, it is widely believed that down-regulation of survivin is one of the important therapeutic functions of Hsp90 inhibitors such as the phase III clinically trialed compound 17-AAG. However, Hsp90 interferes with a number of molecules that up-regulate the intracellular level of survivin, raising the question that clinical use of Hsp90 inhibitors may indirectly induce survivin expression and subsequently enhance cancer anti-drug responses. The purpose of this study is to determine whether targeting Hsp90 can alter survivin expression differently in different cancer cell lines and to explore possible mechanisms that cause the alteration in survivin expression. Notes This is an open access article distributed under the terms of the attached BioMed Central License. See license for details. Language eng Field of Research 111201 Cancer Cell Biology Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2010, Cheung et al. Persistent URL http://hdl.handle.net/10536/DRO/DU:30026574 Document type: Journal Article Collections: Centre for Biotechnology and Interdisciplinary Sciences (BioDeakin) Open Access Collection Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Thu, 01 Apr 2010, 14:17:17 EST Wed, 07 Apr 2010, 08:22:26 EST Fri, 16 Apr 2010, 11:12:16 EST Fri, 16 Apr 2010, 11:13:46 EST Mon, 19 Apr 2010, 11:21:36 EST Mon, 19 Apr 2010, 11:22:56 EST Mon, 19 Apr 2010, 12:09:01 EST Tue, 20 Apr 2010, 23:49:22 EST Fri, 28 May 2010, 09:28:48 EST Wed, 02 Jun 2010, 14:06:14 EST Mon, 13 Dec 2010, 15:10:17 EST Tue, 14 Dec 2010, 08:11:08 EST Thu, 13 Jan 2011, 18:24:56 EST Mon, 17 Jan 2011, 11:04:57 EST Filtered Full Citation counts:   Cited 18 times in TR Web of Science Cited 21 times in Scopus Search Google Scholar Access Statistics: 393 Abstract Views, 75 File Downloads  -  Detailed Statistics Created: Thu, 01 Apr 2010, 14:17:14 EST by Jagat Kanwar

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.