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Irreversible and bivalent ligands for selected G-protein coupled receptors

McNaughton, Michael. 2002, Irreversible and bivalent ligands for selected G-protein coupled receptors, Ph.D. thesis, School of Biological and Chemical Sciences and Centre for Chiral Molecular Technologies, Deakin University.


Title Irreversible and bivalent ligands for selected G-protein coupled receptors
Author McNaughton, Michael.
Institution Deakin University
School School of Biological and Chemical Sciences
Centre for Chiral Molecular Technologies
Faculty Faculty of Science and Technology
Degree name Ph.D.
Date submitted 2002
Keyword(s) Cardiovascular pharmacology
Cardiovascular receptors
Hypertension
Receptor-ligand complexes - Research
Cell receptors - Research
Angiotensin - Receptors
Synthetic drugs
Agonists, Chemical
Summary Derivatives of pharmaceutical compounds that could potentially bind irreversibly to a hypertension controlling receptor were synthesised to provide tools for studying this receptor. Also compounds that simultaneously activate two cardiovascular receptors with opposing cellular mechanisms were synthesised. This resulted in a desired partial reduction in the activity of one receptor.
Language eng
Description of original xxii, 230 leaves : ill. ; 30 cm.
Dewey Decimal Classification 615.71
Persistent URL http://hdl.handle.net/10536/DRO/DU:30026614

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Created: Thu, 01 Apr 2010, 15:45:18 EST

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