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Identification of genes in the liver of Psammomys obesus associated with Type II diabetes

Snelling, Hayley. 2000, Identification of genes in the liver of Psammomys obesus associated with Type II diabetes, M.Sc. thesis, School of Health Sciences, Deakin University.

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Title Identification of genes in the liver of Psammomys obesus associated with Type II diabetes
Author Snelling, Hayley.
Institution Deakin University
School School of Health Sciences
Faculty Faculty of Health and Behavioural Sciences
Degree name M.Sc.
Date submitted 2000
Keyword(s) Non-insulin-dependent diabetes - Pathogenesis
Obesity - Pathophysiology
Calpain
Calpastatin
Gene expression
Summary Type II diabetes is characterised by hyperglycemia and disturbances of fat, carbohydrate and protein metabolism. It occurs mainly in adults, with obesity being the most modifiable risk factor. This project utilised the Israeli Sand Rat (Psammomys obesus) and some of the latest molecular biology technology including differential display, membrane microarray and real-time PCR to detect genes in the liver that may be associated with the development of Type II diabetes and/or obesity. This study showed calpain, a proteolytic inhibitor and calpastatin, its natural inhibitor to be disregulated in the liver during the diabetic state.
Language eng
Description of original [ix], 131 leaves ; 30 cm.
Dewey Decimal Classification 616.462
Persistent URL http://hdl.handle.net/10536/DRO/DU:30027928

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Created: Thu, 01 Apr 2010, 16:07:51 EST

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