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Multicentric carpal-tarsal osteolysis with nephropathy treated successfully with cyclosporine A : a case report and literature review

Connor, Andrew, Highton, John, Hung, Noelyn Anne, Dunbar, John, MacGinley, Robert and Walker, Robert 2007, Multicentric carpal-tarsal osteolysis with nephropathy treated successfully with cyclosporine A : a case report and literature review, American journal of kidney diseases, vol. 50, no. 4, pp. 649-654, doi: 10.1053/j.ajkd.2007.06.014.

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Title Multicentric carpal-tarsal osteolysis with nephropathy treated successfully with cyclosporine A : a case report and literature review
Author(s) Connor, Andrew
Highton, John
Hung, Noelyn Anne
Dunbar, John
MacGinley, RobertORCID iD for MacGinley, Robert orcid.org/0000-0003-2329-0779
Walker, Robert
Journal name American journal of kidney diseases
Volume number 50
Issue number 4
Start page 649
End page 654
Total pages 6
Publisher W.B. Saunders
Place of publication Philadelphia, Pa.
Publication date 2007-10
ISSN 0272-6386
Summary Multicentric carpal-tarsal osteolysis is a rare skeletal disorder characterized by osteolysis of the metacarpal, carpal, and tarsal bones and leading to crippling joint deformities. Progressive nephropathy occurs in more than half the cases. All previously reported series with renal biopsies showed only end-stage renal disease on histological examination because of the late presentation to nephrologists. Accurate diagnosis of the underlying renal pathological state therefore has not been possible. We report the first case in which early and sequential renal biopsies were performed. These show the renal lesion to be focal and segmental glomerulosclerosis, which was treated successfully with cyclosporine A.
Language eng
DOI 10.1053/j.ajkd.2007.06.014
Field of Research 110312 Nephrology and Urology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2007, W.B. Saunders
Persistent URL http://hdl.handle.net/10536/DRO/DU:30028137

Document type: Journal Article
Collection: School of Medicine
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