Acquisition of invasion‐inhibitory antibodies specific for the 19‐kDa fragment of merozoite surface protein 1 in a transmigrant population requires multiple infections

Murhandarwati, E. Elsa Herdiana, Black, Casilda G., Wang, Lina, Weisman, Simon, de Koning-Ward, Tania F., Baird, J. Kevin, Tjitra, Emiliana, Richie, Thomas L., Crabb, Brendan S. and Coppel, Ross L. 2008, Acquisition of invasion‐inhibitory antibodies specific for the 19‐kDa fragment of merozoite surface protein 1 in a transmigrant population requires multiple infections, The journal of infectious diseases, vol. 198, no. 8, pp. 1212-1218.

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Title Acquisition of invasion‐inhibitory antibodies specific for the 19‐kDa fragment of merozoite surface protein 1 in a transmigrant population requires multiple infections
Author(s) Murhandarwati, E. Elsa Herdiana
Black, Casilda G.
Wang, Lina
Weisman, Simon
de Koning-Ward, Tania F.
Baird, J. Kevin
Tjitra, Emiliana
Richie, Thomas L.
Crabb, Brendan S.
Coppel, Ross L.
Journal name The journal of infectious diseases
Volume number 198
Issue number 8
Start page 1212
End page 1218
Total pages 7
Publisher University of Chicago Press
Place of publication Chicago, Ill.
Publication date 2008-10
ISSN 0022-1899
1537-6613
Summary Antibodies against the 19 kDa C‐terminal fragment of merozoite surface protein 1 (MSP119) are a major component of the invasion‐inhibitory response in individuals immune to malaria. We report here the acquisition of MSP119‐specific invasion‐inhibitory antibodies in a group of transmigrants who experienced their sequential malaria infections during settlement in an area of Indonesia where malaria is highly endemic. We used 2 transgenic Plasmodium falciparum parasite lines that expressed either endogenous MSP119 or the homologous region from P. chabaudi to measure the MSP119‐specific invasion‐inhibitory antibodies. The results revealed that the acquisition of MSP119‐specific invasion‐inhibitory antibodies required 2 or more P. falciparum infections. In contrast, enzyme‐linked immunosorbent assays on the same serum samples showed that MSP119‐specific antibodies are present after the first malaria infection. This delay in the acquisition of functional antibodies by residents of areas where malaria is endemic is consistent with the observation that multiple malaria infections are required before clinical immunity is acquired.
Language eng
Field of Research 110802 Medical Infection Agents (incl Prions)
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2008, Infectious Diseases Society of America
Persistent URL http://hdl.handle.net/10536/DRO/DU:30028138

Document type: Journal Article
Collection: School of Medicine
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