A systematic review of the quality of liver biopsy specimens

Cholongitas, Evangelos, Senzolo, Marco, Standish, Richard, Marelli, Laura, Quaglia, Alberto, Patch, David, Dhillon, Amar P. and Burroughs, Andrew Kenneth 2006, A systematic review of the quality of liver biopsy specimens, American journal of clinical pathology, vol. 125, no. 5, pp. 710-721, doi: 10.1309/W3XCNT4HKFBN2G0B.

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Title A systematic review of the quality of liver biopsy specimens
Author(s) Cholongitas, Evangelos
Senzolo, Marco
Standish, Richard
Marelli, Laura
Quaglia, Alberto
Patch, David
Dhillon, Amar P.
Burroughs, Andrew Kenneth
Journal name American journal of clinical pathology
Volume number 125
Issue number 5
Start page 710
End page 721
Total pages 12
Publisher American Society for Clinical Pathology
Place of publication Chicago, Il.
Publication date 2006
ISSN 0002-9173
Summary Characteristics for an optimal liver biopsy specimen were recently defined as 20 to 25 mm long and/or containing more than 11 complete portal tracts (CPTs). A systematic review of percutaneous liver biopsy (PLB) and transjugular liver biopsy (TJLB) series yielded only 32 PLB studies in which these characteristics were evaluated: mean ± SD length, 17.7 ± 5.8 mm and number of CPTs, 7.5 ± 3.4; and 15 TJLB studies: mean ± SD length, 13.5 ± 4.5 mm and number of CPTs, 6.8 ± 2.3. Studies of sampling heterogeneity and intraobserver and interobserver variability also used inadequate specimens by present standards. Only 11 (5.3%) of 207 therapeutic studies for chronic hepatitis B and C documented length and/or number of CPTs. Of the current 12 studies evaluating noninvasive fibrosis tests, only 8 documented length or number of CPTs, and only 1 documented length and number of CPTs. New studies are needed based on adequate liver biopsy samples to provide reliable estimation of grading and staging in chronic liver disease.
Language eng
Field of Research 110307 Gastroenterology and Hepatology
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©American Society for Clinical Pathology
Persistent URL http://hdl.handle.net/10536/DRO/DU:30028147

Document type: Journal Article
Collection: School of Medicine
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