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A new rodent model to assess blood stage immunity to the plasmodium falciparum antigen merozoite surface protein 119 reveals a protective role for invasion inhibitory antibodies

de Koning-Ward, Tania F., O'Donnell, Rebecca A., Drew, Damien R., Thomson, Russell, Speed, Terence P. and Crabb, Brendan S. 2003, A new rodent model to assess blood stage immunity to the plasmodium falciparum antigen merozoite surface protein 119 reveals a protective role for invasion inhibitory antibodies, The journal of experimental medicine, vol. 198, no. 6, pp. 869-875.

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Title A new rodent model to assess blood stage immunity to the plasmodium falciparum antigen merozoite surface protein 119 reveals a protective role for invasion inhibitory antibodies
Author(s) de Koning-Ward, Tania F.
O'Donnell, Rebecca A.
Drew, Damien R.
Thomson, Russell
Speed, Terence P.
Crabb, Brendan S.
Journal name The journal of experimental medicine
Volume number 198
Issue number 6
Start page 869
End page 875
Publisher Rockefeller University Press
Place of publication New York, N. Y.
Publication date 2003-09-15
ISSN 0022-1007
1540-9538
Summary Antibodies capable of inhibiting the invasion of Plasmodium merozoites into erythrocytes are present in individuals that are clinically immune to the malaria parasite. Those targeting the 19-kD COOH-terminal domain of the major merozoite surface protein (MSP)-119 are a major component of this inhibitory activity. However, it has been difficult to assess the overall relevance of such antibodies to antiparasite immunity. Here we use an allelic replacement approach to generate a rodent malaria parasite (Plasmodium berghei) that expresses a human malaria (Plasmodium falciparum) form of MSP-119. We show that mice made semi-immune to this parasite line generate high levels of merozoite inhibitory antibodies that are specific for P. falciparum MSP-119. Importantly, protection from homologous blood stage challenge in these mice correlated with levels of P. falciparum MSP-119–specific inhibitory antibodies, but not with titres of total MSP-119–specific immunoglobulins. We conclude that merozoite inhibitory antibodies generated in response to infection can play a significant role in suppressing parasitemia in vivo. This study provides a strong impetus for the development of blood stage vaccines designed to generate invasion inhibitory antibodies and offers a new animal model to trial P. falciparum MSP-119 vaccines.
Language eng
Field of Research 110803 Medical Parasitology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2003, Rockefeller University Press
Persistent URL http://hdl.handle.net/10536/DRO/DU:30028155

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.