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Sustained low-efficiency dialysis with filtration (SLEDD-f) in the management of acute sodium valproate intoxication

Khan, Emon, Huggan, Paul, Celi, Leo, MacGinley, Robert, Schollum, John and Walker, Robert 2008, Sustained low-efficiency dialysis with filtration (SLEDD-f) in the management of acute sodium valproate intoxication, Hemodialysis international, vol. 12, no. 2, pp. 211-214, doi: 10.1111/j.1542-4758.2008.00254.x.

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Title Sustained low-efficiency dialysis with filtration (SLEDD-f) in the management of acute sodium valproate intoxication
Author(s) Khan, Emon
Huggan, Paul
Celi, Leo
MacGinley, RobertORCID iD for MacGinley, Robert orcid.org/0000-0003-2329-0779
Schollum, John
Walker, Robert
Journal name Hemodialysis international
Volume number 12
Issue number 2
Start page 211
End page 214
Total pages 4
Publisher Wiley-Blackwell Publishing
Place of publication Malden, Ma.
Publication date 2008
ISSN 1492-7535
Summary Hemodialysis is only infrequently used in drug overdosage situations. The efficacy of hemodialysis to remove the drug depends upon the pharmacokinetics and pharmacodynamics of the drug. At normal therapeutic concentrations, valproic acid is predominantly protein bound and therefore removal by hemodialysis is limited. In an overdose situation, protein binding is rapidly saturated and therefore the substantially larger quantities of the free drug can rapidly cause toxicity. Slow low-efficient daily diafiltration (SLEDD) has not previously been utilized in a drug overdose situation. We report the effective use of SLEDD to remove high toxic concentrations of valproic acid in an overdose situation. Slow low-efficient daily diafiltration also prevented the rebound phenomenon that can occur as the excess drug is released from its protein-bound stores. Hybrid dialysis therapies deserve further evaluation in the management of other poisonings where extra-corporeal therapy is indicated.
Language eng
DOI 10.1111/j.1542-4758.2008.00254.x
Field of Research 110312 Nephrology and Urology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2008, Wiley-Blackwell Publishing
Persistent URL http://hdl.handle.net/10536/DRO/DU:30028177

Document type: Journal Article
Collection: School of Medicine
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