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Benign recurrent intrahepatic cholestasis with secondary renal impairment treated with extracorporeal albumin dialysis

Saich, Rebecca, Collins, Peter, Ala, Aftab, Standish, Richard A. and Hodgson, Humphrey 2005, Benign recurrent intrahepatic cholestasis with secondary renal impairment treated with extracorporeal albumin dialysis, European journal of gastroenterology and hepatology, vol. 17, no. 5, pp. 585-588.

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Title Benign recurrent intrahepatic cholestasis with secondary renal impairment treated with extracorporeal albumin dialysis
Author(s) Saich, Rebecca
Collins, Peter
Ala, Aftab
Standish, Richard A.
Hodgson, Humphrey
Journal name European journal of gastroenterology and hepatology
Volume number 17
Issue number 5
Start page 585
End page 588
Total pages 4
Publisher Lippincott Williams & Wilkins Inc
Place of publication Philadelphia, Pa.
Publication date 2005-05
ISSN 0954-691X
Summary Benign recurrent intrahepatic cholestasis (BRIC) is a rare autosomal recessive condition characterized by intermittent episodes of pruritis and jaundice that may last days to months. Treatment is often ineffective and symptoms, particularly pruritis, can be severe. Extracorporeal albumin dialysis (molecular adsorbent recycling system, MARS) is a novel treatment which removes albumin bound toxins including bilirubin and bile salts. We describe a case of a 34-year-old man with BRIC and secondary renal impairment who, having failed standard medical therapy, was treated with MARS. The treatment immediately improved his symptoms, renal and liver function tests and appeared to terminate the episode of cholestasis. We conclude that MARS is a safe and effective treatment for BRIC with associated renal impairment.
Language eng
Field of Research 110312 Nephrology and Urology
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2005, Lippincott Williams & Wilkins, Inc.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30028207

Document type: Journal Article
Collection: School of Medicine
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