An appraisal of the histopathological assessment of liver fibrosis.

Standish, R.A., Cholongitas, E., Dhillon, A., Burroughs, A.K. and Dhillon, A.P. 2006, An appraisal of the histopathological assessment of liver fibrosis., Gut : an international journal of gastroenterology & hepatology, vol. 55, no. 4, pp. 569-578, doi: 10.1136/gut.2005.084475.

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Title An appraisal of the histopathological assessment of liver fibrosis.
Author(s) Standish, R.A.
Cholongitas, E.
Dhillon, A.
Burroughs, A.K.
Dhillon, A.P.
Journal name Gut : an international journal of gastroenterology & hepatology
Volume number 55
Issue number 4
Start page 569
End page 578
Total pages 10
Publisher B M J Publishing Group
Place of publication London, England
Publication date 2006
ISSN 0017-5749
Summary One of the most important aspects of the histopathological assessment of liver biopsies in the setting of chronic liver disease is determination of the degree of fibrosis and architectural change. Most of the work in this regard has been concerned with chronic viral hepatitis. This article attempts to assess critically our current and historical biopsy practice, from subjective fibrosis scoring systems to biopsy sample size; and the appropriate use of the data that scoring systems
generate in the research and clinical setting. An understanding of the limitations of each of the components of the fibrosis assessment process can help to devise appropriate protocols to ensure that the information obtained is optimised, and its degree of reliability appreciated. It is only from this starting point that recently promulgated antifibrotic medications and ‘‘non-invasive’’ liver fibrosis assessment techniques can be evaluated properly.
Language eng
DOI 10.1136/gut.2005.084475
Field of Research 110307 Gastroenterology and Hepatology
HERDC Research category C1.1 Refereed article in a scholarly journal
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Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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