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Multicellular spheroids in ovarian cancer metastases: Biology and pathology

Shield, Kristy, Ackland, M. Leigh, Ahmed, Nuzhat and Rice, Gregory E. 2009, Multicellular spheroids in ovarian cancer metastases: Biology and pathology, Gynecologic oncology, vol. 113, no. 1, pp. 143-148, doi: 10.1016/j.ygyno.2008.11.032.

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Title Multicellular spheroids in ovarian cancer metastases: Biology and pathology
Author(s) Shield, Kristy
Ackland, M. LeighORCID iD for Ackland, M. Leigh orcid.org/0000-0002-7474-6556
Ahmed, Nuzhat
Rice, Gregory E.
Journal name Gynecologic oncology
Volume number 113
Issue number 1
Start page 143
End page 148
Total pages 6
Publisher Academic Press
Place of publication San Diego, Calif.
Publication date 2009-04
ISSN 1095-6859
0090-8258
Keyword(s) epithelial ovarian cancer
spheroids
metastasis
chemotherapy
chemo-resistance
Summary Epithelial ovarian cancer (EOC) has a relatively high mortality rate (~55%). One of the presiding causes is that the current chemotherapeutic regimes are unable to achieve sustained remission, despite frequently producing a positive response at first treatment. One of the reasons that EOC is difficult to treat is that the mechanism of dissemination is unusual. EOC dissemination characteristically involves local invasion of pelvic and abdominal organs. Unlike many epithelial cancers, initial dissemination rarely requires the vasculature, although the vasculature is often implicated in the advanced stages of disease. Recently, it has become apparent that aggregates of malignant cells (spheroids) contained within malignant ascites represent a significant impediment to efficacious treatment of late stage EOC. In vivo, spheroids are present in the malignant ascites of EOC patients, while in vitro cultured spheroids are capable of tumorgenesis in vivo and display a reduced response to chemotherapeutic drugs when compared to monolayers. A major problem associated with the current generation of chemotherapy agents is that they do not address the anchorage and vascular-independent growth conditions associated with a 3-dimensional structure that has formed and/or grown in suspension. Thus, spheroid formation may represent a key component of platinum/taxanesensitive recurrence. If this is correct, a better understanding of spheroid biology may contribute to the identification of new treatment opportunities for the sustained treatment of metastatic EOC. This review article outlines the key biological features of spheroids, specifically discussing their role in EOC dissemination and chemo-response as well as providing insights into spheroid functionality.
Language eng
DOI 10.1016/j.ygyno.2008.11.032
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2009
Copyright notice ©2008, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30028353

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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Created: Fri, 16 Apr 2010, 12:49:00 EST by Teresa Treffry

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