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Synthesis of a novel pyrrole oxazole analogue of the insecticide pirate

Loughlin, Wendy A., Murphy, Michelle E., Elson, Kathryn E. and Henderson, Luke C. 2004, Synthesis of a novel pyrrole oxazole analogue of the insecticide pirate, Australian journal of chemistry, vol. 57, no. 3, pp. 227-232, doi: 10.1071/CH03184.

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Title Synthesis of a novel pyrrole oxazole analogue of the insecticide pirate
Author(s) Loughlin, Wendy A.
Murphy, Michelle E.
Elson, Kathryn E.
Henderson, Luke C.ORCID iD for Henderson, Luke C. orcid.org/0000-0002-4244-2056
Journal name Australian journal of chemistry
Volume number 57
Issue number 3
Start page 227
End page 232
Publisher CSIRO Publishing
Place of publication Collingwood, Vic.
Publication date 2004
ISSN 0004-9425
1445-0038
Summary The pyrrole oxazole 4 is a novel analogue of the broad-spectrum insecticide and miticide pirate 2. The expedient synthesis of pyrrole oxazole 4 in six steps from pyrrole is reported using a synthetic route that could have potential for the solution-phase combinatorial synthesis of analogues. Preliminary biological evaluation of the protected pyrrole oxazole 4 (LD50 1.13 μg mL–1) and the deprotected pyrrole oxazole 5 (LD50 1.06 μg mL–1) for potential cytotoxicity was carried out.
Language eng
DOI 10.1071/CH03184
Field of Research 030503 Organic Chemical Synthesis
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2004, CSIRO
Persistent URL http://hdl.handle.net/10536/DRO/DU:30028587

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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Created: Wed, 12 May 2010, 12:48:49 EST by Leanne Swaneveld

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