HIV-1 vaccine development : tackling virus diversity with a multi-envelope cocktail

Hurwitz, Julia L., Zhan, Xiaoyan, Brown, Scott A., Bonsignori, Mattia, Stambas, John, Lockey, Timothy D., Sealy, Robert, Surman, Sherri, Freiden, Pam, Jones, Bart, Martin, Louis, Blanchard, James and Slobod, Karen S. 2008, HIV-1 vaccine development : tackling virus diversity with a multi-envelope cocktail, Frontiers in Bioscience, vol. 13, no. 2, pp. 609-620, doi: 10.2741/2706.

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Title HIV-1 vaccine development : tackling virus diversity with a multi-envelope cocktail
Author(s) Hurwitz, Julia L.
Zhan, Xiaoyan
Brown, Scott A.
Bonsignori, Mattia
Stambas, JohnORCID iD for Stambas, John
Lockey, Timothy D.
Sealy, Robert
Surman, Sherri
Freiden, Pam
Jones, Bart
Martin, Louis
Blanchard, James
Slobod, Karen S.
Journal name Frontiers in Bioscience
Volume number 13
Issue number 2
Start page 609
End page 620
Total pages 12
Publisher Frontiers in bioscience
Place of publication Tampa, U.S.A.
Publication date 2008-01-01
ISSN 1093-9946
Summary A major obstacle to the design of a global HIV-1 vaccine is viral diversity. At present, data suggest that a vaccine comprising a single antigen will fail to generate broadly reactive B-cell and T-cell responses able to confer protection against the diverse isolates of HIV-1. While some B-cell and T-cell epitopes lie within the more conserved regions of HIV-1 proteins, many are localized to variable regions and differ from one virus to the next. Neutralizing B-cell responses may vary toward viruses with different i) antibody contact residues and/or ii) protein conformations while T-cell responses may vary toward viruses with different (i) T-cell receptor contact residues and/or (ii) amino acid sequences pertinent to antigen processing. Here we review previous and current strategies for HIV-1 vaccine development. We focus on studies at St. Jude Children's Research Hospital (SJCRH) dedicated to the development of an HIV-1 vaccine cocktail strategy. The SJCRH multi-vectored, multi-envelope vaccine has now been shown to elicit HIV-1-specific B- and T-cell functions with a diversity and durability that may be required to prevent HIV-1 infections in humans.
Language eng
DOI 10.2741/2706
Field of Research 110804 Medical Virology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Grant ID NHMRC 508902
Copyright notice ©2008 Frontiers in Bioscience
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