Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity

Kedzierska, Katherine, La Gruta, Nicole L., Stambas, John, Turner, Stephen J. and Doherty, Peter C. 2008, Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity, Molecular Immunology, vol. 45, no. 3, pp. 607-618.

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Title Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity
Author(s) Kedzierska, Katherine
La Gruta, Nicole L.
Stambas, John
Turner, Stephen J.
Doherty, Peter C.
Journal name Molecular Immunology
Volume number 45
Issue number 3
Start page 607
End page 618
Total pages 12
Publisher Pergamon Press
Place of publication Oxford, England
Publication date 2008-02
ISSN 0161-5890
1872-9142
Keyword(s) CD8+ cells
T cell receptor repertoire
CD62L
Memory
Influenza A virus
Summary Antigen-specific T cell receptors (TCRs) recognise complexes of immunogenic peptides (p) and major histocompatibility complex (MHC) glycoproteins. Responding T cell populations show profiles of preferred usage (or bias) toward one or few TCRβ chains. Such skewing is also observed, though less commonly, in TCRα chain usage. The extent and character of clonal diversity within individual, antigen-specific T cell sets can be established by sequence analysis of the TCRVβ and/or TCRVα CDR3 loops. The present review provides examples of such TCR repertoires in prominent responses to acute and persistent viruses. The determining role of structural constraints and antigen dose is discussed, as is the way that functionally and phenotypically distinct populations can be defined at the clonal level. In addition, clonal dissection of “high” versus “low” avidity, or “central” versus “effector” memory sets provides insights into how these antigen specific T cell responses are generated and maintained. As TCR diversity potentially influences both the protective capacity of CD8+ T cells and the subversion of immune control that leads to viral escape, analysing the spectrum of TCR selection and maintenance has implications for improving the functional efficacy of T cell responsiveness and effector function.
Language eng
Field of Research 110702 Applied Immunology (incl Antibody Engineering, Xenotransplantation and T-cell Therapies)
Socio Economic Objective 920108 Immune System and Allergy
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ┬ęCopyright 2007 Elsevier Ltd All rights reserved.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30028851

Document type: Journal Article
Collection: School of Medicine
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