Location rather than CD62L phenotype is critical in the early establishment of influenza-specific T cell memory

Kedzierska, Katherine, Stambas, John, Jenkins, Misty R., Keating, Rachael, Turner, Stephen J. and Doherty, Peter C. 2007, Location rather than CD62L phenotype is critical in the early establishment of influenza-specific T cell memory, Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 23, pp. 9782-9787.

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Title Location rather than CD62L phenotype is critical in the early establishment of influenza-specific T cell memory
Author(s) Kedzierska, Katherine
Stambas, John
Jenkins, Misty R.
Keating, Rachael
Turner, Stephen J.
Doherty, Peter C.
Journal name Proceedings of the National Academy of Sciences of the United States of America
Volume number 104
Issue number 23
Start page 9782
End page 9787
Publisher National Academy of Sciences
Place of publication Washington, D.C.
Publication date 2007-06
ISSN 0027-8424
1091-6490
Keyword(s) draining lymph nodes
generation of memory
Summary The rapid recall of influenza virus-specific CD8+ T cell effector function is protective, although our understanding of T cell memory remains incomplete. Recent debate has focused particularly on the CD62L lymph node homing receptor. The present analysis shows that although functional memory can be established from both CD62Lhi and CD62Llo CD8+ T cell subsets soon after initial encounter between naive precursors and antigen, the optimal precursors are CD8+CD44hiCD25lo immune lymphocytes isolated from draining lymph nodes on day 3.5 after influenza virus infection. Analysis of primed T cells at different times after challenge indicates that the capacity to transfer memory is diminished at the peak of the primary cytotoxic T lymphocyte response, challenging speculations that the transition to memory first requires full differentiation to effector status. It seems that location rather than CD62Lhi/lo phenotype may be the more profitable focus for further dissection of the early establishment of T cell memory.
Language eng
Field of Research 110804 Medical Virology
Socio Economic Objective 920109 Infectious Diseases
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice © 2007 by The National Academy of Sciences of the USA
Persistent URL http://hdl.handle.net/10536/DRO/DU:30028853

Document type: Journal Article
Collection: School of Medicine
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