A question of self-preservation : immunopathology in influenza virus infection

La Gruta, Nicole L., Kedzierska, Katherine, Stambas, John and Doherty, Peter C. 2007, A question of self-preservation : immunopathology in influenza virus infection, Immunology and Cell Biology, vol. 85, no. 2, pp. 85-92.

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Title A question of self-preservation : immunopathology in influenza virus infection
Author(s) La Gruta, Nicole L.
Kedzierska, Katherine
Stambas, John
Doherty, Peter C.
Journal name Immunology and Cell Biology
Volume number 85
Issue number 2
Start page 85
End page 92
Publisher Nature Publishing Group
Place of publication Adelaide, S. Aust.
Publication date 2007-02
ISSN 0818-9641
1440-1711
Keyword(s) chemokines
cytokines
immunopathology
influenza A virus
macrophages
T cells
Summary Influenza A viruses that circulate normally in the human population cause a debilitating, though generally transient, illness that is sometimes fatal, particularly in the elderly. Severe complications arising from pandemic influenza or the highly pathogenic avian H5N1 viruses are often associated with rapid, massive inflammatory cell infiltration, acute respiratory distress, reactive hemophagocytosis and multiple organ involvement. Histological and pathological indicators strongly suggest a key role for an excessive host response in mediating at least some of this pathology. Here, we review the current literature on how various effector arms of the immune system can act deleteriously to initiate or exacerbate pathological damage in this viral pneumonia. Generally, the same immunological factors mediating tissue damage during the anti-influenza immune response are also critical for efficient elimination of virus, thereby posing a significant challenge in the design of harmless yet effective therapeutic strategies for tackling influenza virus.
Language eng
Field of Research 110804 Medical Virology
Socio Economic Objective 920108 Immune System and Allergy
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2007 Australasian Society for Immunology Inc. All rights reserved
Persistent URL http://hdl.handle.net/10536/DRO/DU:30028855

Document type: Journal Article
Collection: School of Medicine
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