Sindbis virus vectors elicit hemagglutinin-specific humoral and cellular immune responses and offer a dose-sparing strategy for vaccination

Miller, Annett, Center, Rob J., Stambas, John, Deliyannis, Georgia, Doherty, Peter C., Howard, Jane L., Turner, Stephen J. and Purcell, Damian F.J. 2008, Sindbis virus vectors elicit hemagglutinin-specific humoral and cellular immune responses and offer a dose-sparing strategy for vaccination, Vaccine, vol. 26, no. 44, pp. 5641-5648.

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Title Sindbis virus vectors elicit hemagglutinin-specific humoral and cellular immune responses and offer a dose-sparing strategy for vaccination
Author(s) Miller, Annett
Center, Rob J.
Stambas, John
Deliyannis, Georgia
Doherty, Peter C.
Howard, Jane L.
Turner, Stephen J.
Purcell, Damian F.J.
Journal name Vaccine
Volume number 26
Issue number 44
Start page 5641
End page 5648
Total pages 8
Publisher Elsevier Ltd.
Place of publication Guildford, England
Publication date 2008-10-16
ISSN 0264-410X
1873-2518
Keyword(s) influenza
vaccine
sindbis
Summary We report here on the use of a Sindbis virus-based DNA-launch RNA replicon vector (pSIN-HA) that expresses influenza hemagglutinin (HA) as an immunogen. Immunization of mice with pSIN-HA generated anti-HA antibody and CTL responses and resulted in lower lung viral titers after influenza challenge when compared to controls. Importantly, immunization with a low dose of pSIN-HA mediated significantly reduced lung viral titers following challenge at 43 weeks after the final immunization. In contrast, immunization with a non-replicon DNA vector expressing HA failed to mediate reduced lung viral titer at the same dose. This demonstrated the dose-sparing capacity of the SIN vector system and its ability to stimulate long-term memory responses, properties that are highly desirable in any vaccine formulation.
Language eng
Field of Research 110804 Medical Virology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ┬ęCopyright 2008 Elsevier Ltd All rights reserved.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30028894

Document type: Journal Article
Collection: School of Medicine
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