Deakin home > Deakin University Library > Deakin Research Online > Influenza A virus-specific CD8.sup.+ T-cell responses : from induction to function

Influenza A virus-specific CD8.sup.+ T-cell responses : from induction to function

Olson, M. R., Russ, B. E., Doherty, P. C., Turner, S. J. and Stambas, J. 2010, Influenza A virus-specific CD8.sup.+ T-cell responses : from induction to function, Future virology, vol. 5, no. 2, pp. 175-183.

Attached Files (Some files may be inaccessible until you login with your Deakin Research Online credentials)
Name Description MIMEType Size Downloads

Title Influenza A virus-specific CD8.sup.+ T-cell responses : from induction to function
Author(s) Olson, M. R.
Russ, B. E.
Doherty, P. C.
Turner, S. J.
Stambas, J.
Journal name Future virology
Volume number 5
Issue number 2
Start page 175
End page 183
Publisher Future Medicine Ltd.
Place of publication London, England
Publication date 2010-03
ISSN 1746-0794
1746-0808
Keyword(s) cytotoxic T lymphocytes
dendritic cells
influenza
vaccination
virus
Summary Seasonal influenza virus infection is a leading cause of illness and mortality in young children and the elderly each year. Current influenza vaccines generate protective antibody responses; however, these must be given annually to provide protection against serologically distinct viruses. By contrast, CD8.sup.+ T cells are capable of recognizing conserved antigenic determinants within the influenza virion and, as such, may provide protection against a number of variant strains of the virus. CD8.sup.+ T cells play a critical key role in controlling and resolving influenza virus infections via the production of cytokines and cytolytic mediators. This article focuses on the induction of the influenza-specific CD8.sup.+ T-cell response and how these cells acquire and maintain effector function after induction. Moreover, we discuss how cytotoxic T-lymphocyte function correlates with protection following vaccination.
Language eng
Field of Research 110309 Infectious Diseases
Socio Economic Objective 920109 Infectious Diseases
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2010, Future Medicine Ltd
Persistent URL http://hdl.handle.net/10536/DRO/DU:30028895

Document type: Journal Article
Collection: School of Medicine
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in Deakin Research Online is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Access Statistics: 291 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Wed, 26 May 2010, 16:07:03 EST