Influenza A virus-specific CD8.sup.+ T-cell responses : from induction to function

Olson, M. R., Russ, B. E., Doherty, P. C., Turner, S. J. and Stambas, J. 2010, Influenza A virus-specific CD8.sup.+ T-cell responses : from induction to function, Future virology, vol. 5, no. 2, pp. 175-183.

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Title Influenza A virus-specific CD8.sup.+ T-cell responses : from induction to function
Author(s) Olson, M. R.
Russ, B. E.
Doherty, P. C.
Turner, S. J.
Stambas, J.
Journal name Future virology
Volume number 5
Issue number 2
Start page 175
End page 183
Total pages 9
Publisher Future Medicine Ltd.
Place of publication London, England
Publication date 2010-03
ISSN 1746-0794
1746-0808
Keyword(s) cytotoxic T lymphocytes
dendritic cells
influenza
vaccination
virus
Summary Seasonal influenza virus infection is a leading cause of illness and mortality in young children and the elderly each year. Current influenza vaccines generate protective antibody responses; however, these must be given annually to provide protection against serologically distinct viruses. By contrast, CD8.sup.+ T cells are capable of recognizing conserved antigenic determinants within the influenza virion and, as such, may provide protection against a number of variant strains of the virus. CD8.sup.+ T cells play a critical key role in controlling and resolving influenza virus infections via the production of cytokines and cytolytic mediators. This article focuses on the induction of the influenza-specific CD8.sup.+ T-cell response and how these cells acquire and maintain effector function after induction. Moreover, we discuss how cytotoxic T-lymphocyte function correlates with protection following vaccination.
Language eng
Field of Research 110309 Infectious Diseases
Socio Economic Objective 920109 Infectious Diseases
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2010, Future Medicine Ltd
Persistent URL http://hdl.handle.net/10536/DRO/DU:30028895

Document type: Journal Article
Collection: School of Medicine
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