HIV vaccine rationale, design and testing

Slobod, Karen S., Coleclough, Chris, Bonsignori, Mattia, Brown, Scott A., Zhan, Xiaoyan, Surman, Sherri, Zirkel, Amy, Jones, Bart G., Sealy, Robert E., Stambas, John, Brown, Brita, Lockey, Timothy D., Freiden, Pamela J., Doherty, Peter C., Blanchard, James L., Martin, Louis N. and Hurwitz, Julia L. 2005, HIV vaccine rationale, design and testing, Current HIV research, vol. 3, no. 2, pp. 107-112.

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Title HIV vaccine rationale, design and testing
Author(s) Slobod, Karen S.
Coleclough, Chris
Bonsignori, Mattia
Brown, Scott A.
Zhan, Xiaoyan
Surman, Sherri
Zirkel, Amy
Jones, Bart G.
Sealy, Robert E.
Stambas, John
Brown, Brita
Lockey, Timothy D.
Freiden, Pamela J.
Doherty, Peter C.
Blanchard, James L.
Martin, Louis N.
Hurwitz, Julia L.
Journal name Current HIV research
Volume number 3
Issue number 2
Start page 107
End page 112
Publisher Bentham Science Publishers Ltd.
Place of publication The Netherlands
Publication date 2005-04
ISSN 1570-162X
1873-4251
Keyword(s) HIV envelope protein
cocktail
breadth
Summary A central obstacle to the design of a global HIV vaccine is viral diversity. Antigenic differences in envelope proteins result in distinct HIV serotypes, operationally defined such that antibodies raised against envelope molecules from one serotype will not bind envelope molecules from a different serotype. The existence of serotypes has presented a similar challenge to vaccine development against other pathogens. In such cases, antigenic diversity has been addressed by vaccine design. For example, the poliovirus vaccine includes three serotypes of poliovirus, and Pneumovax® presents a cocktail of 23 pneumococcal variants to the immune system. It is likely that a successful vaccine for HIV must also comprise a cocktail of antigens. Here, data relevant to the development of cocktail vaccines, designed to harness diverse, envelope-specific Bcell and T-cell responses, are reviewed.
Language eng
Field of Research 110804 Medical Virology
Socio Economic Objective 920109 Infectious Diseases
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice © 2005 Bentham Science Publishers Ltd.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30028905

Document type: Journal Article
Collection: School of Medicine
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