Killer T cells in influenza

Stambas, John, Guillonneau, Carole, Kedzierska, Katherine, Mintern, Justine D., Doherty, Peter C. and La Gruta, Nicole L. 2008, Killer T cells in influenza, Pharmacology and Therapeutics, vol. 120, no. 2, pp. 186-196.

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Title Killer T cells in influenza
Author(s) Stambas, John
Guillonneau, Carole
Kedzierska, Katherine
Mintern, Justine D.
Doherty, Peter C.
La Gruta, Nicole L.
Journal name Pharmacology and Therapeutics
Volume number 120
Issue number 2
Start page 186
End page 196
Total pages 11
Publisher Elsevier Ltd.
Place of publication Oxford, England
Publication date 2008-11
ISSN 0163-7258
Keyword(s) Influenza
CD8+ T cells
Cytotoxicity
Memory
TCR repertoire
Vaccine
Ageing
Summary Antigen-specific CD8+ T cells play an important role in virus clearance. Here we review the current understanding of influenza virus-specific CD8+ T cell immunity in experimental mouse models and humans. The characteristics and nature of CD8+ T cell killing are discussed, as is the selection and maintenance of the influenza-specific effector and memory repertoires. Consideration is given to vaccine strategies and to the effects of ageing. Understanding the complexities of CD8+ T cell mediated immunity and memory has the potential for improving vaccine design, particularly to combat pandemics caused by newly emerging influenza viruses.
Language eng
Field of Research 110804 Medical Virology
Socio Economic Objective 920109 Infectious Diseases
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ┬ęCopyright 2010 Elsevier Inc. All rights reserved.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30028911

Document type: Journal Article
Collection: School of Medicine
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