Stambas, John, Guillonneau, Carole, Kedzierska, Katherine, Mintern, Justine D., Doherty, Peter C. and La Gruta, Nicole L. 2008, Killer T cells in influenza, Pharmacology and Therapeutics, vol. 120, no. 2, pp. 186-196, doi: 10.1016/j.pharmthera.2008.08.007.
Antigen-specific CD8+ T cells play an important role in virus clearance. Here we review the current understanding of influenza virus-specific CD8+ T cell immunity in experimental mouse models and humans. The characteristics and nature of CD8+ T cell killing are discussed, as is the selection and maintenance of the influenza-specific effector and memory repertoires. Consideration is given to vaccine strategies and to the effects of ageing. Understanding the complexities of CD8+ T cell mediated immunity and memory has the potential for improving vaccine design, particularly to combat pandemics caused by newly emerging influenza viruses.
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