Oxidised mannan as a novel adjuvant inducing mucosal IgA production.

Stambas, John, Pietersz, Geoffrey, McKenzie, Ian and Cheers, Christina 2002, Oxidised mannan as a novel adjuvant inducing mucosal IgA production., Vaccine, vol. 20, no. 7-8, pp. 1068-1078.

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Title Oxidised mannan as a novel adjuvant inducing mucosal IgA production.
Author(s) Stambas, John
Pietersz, Geoffrey
McKenzie, Ian
Cheers, Christina
Journal name Vaccine
Volume number 20
Issue number 7-8
Start page 1068
End page 1078
Publisher Elsevier Ltd.
Place of publication Guildford, England
Publication date 2002-01-15
ISSN 0264-410X
Keyword(s) mucosa
IgA
oxidised mannan
Summary Mannan, oxidatively coupled to recombinant protein antigens, has here been tested as a possible adjuvant for the production of antibody on the mucosa. Given intranasally, but not intraperitoneally, mannan markedly enhanced the production of IgA, IgG1 and IgG2a in the serum, and IgA locally in the lung and at remote mucosal sites, including tears, vaginal and salivary secretions. Oxidative coupling was critical to its action, since neither mannan simply mixed with protein nor mannan–protein conjugates which had been reduced by treatment with sodium borohydride, acted as adjuvants. Oxidatively coupled mannan was compared with the widely studied mucosal adjuvant, cholera toxin (CT). The use of oxidised mannan as an adjuvant induced better responses than CT judged by the induction of IgA in serum, vaginal washings and saliva. Thus, oxidised mannan, which is non-toxic and can be administered without injection, is a suitable adjuvant coupled with protective antigens for vaccinating against a number of infections that occur via the mucous membranes.
Language eng
Field of Research 110804 Medical Virology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ┬ęCopyright 2002 Elsevier Science Ltd. All rights reserved.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30028912

Document type: Journal Article
Collection: School of Medicine
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