Oxidised mannan-listeriolysin O conjugates induce Th1/Th2 cytokine responses after intranasal immunisation

Stambas, John, Pietersz, Geoffrey, McKenzie, Ian, Nagabhushanam, Vijaya and Cheers, Christina 2002, Oxidised mannan-listeriolysin O conjugates induce Th1/Th2 cytokine responses after intranasal immunisation, Vaccine, vol. 20, no. 13-14, pp. 1877-1886.

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Title Oxidised mannan-listeriolysin O conjugates induce Th1/Th2 cytokine responses after intranasal immunisation
Author(s) Stambas, John
Pietersz, Geoffrey
McKenzie, Ian
Nagabhushanam, Vijaya
Cheers, Christina
Journal name Vaccine
Volume number 20
Issue number 13-14
Start page 1877
End page 1886
Publisher Elsevier Ltd.
Place of publication Guildford, England
Publication date 2002-03-15
ISSN 0264-410X
Keyword(s) Adjuvant
Th1
Th2
Oxidised mannan
Summary Clearance of infectious organisms does not always require polarised Th1 or Th2 responses and it may be advantageous for both Th1 and Th2 responses to be elicited for effective protection against an invading pathogen. It was the aim of this study to investigate oxidised mannan as a possible Th1/Th2 adjuvant. Oxidised mannan was conjugated to two candidate antigens and delivered intranasally to mice. Immunisation with the oxidised conjugate resulted in significant antigen specific proliferative responses, IL-2, IFN-γ and IL-4 production when compared to unconjugated controls.
Language eng
Field of Research 110804 Medical Virology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ┬ęCopyright 2002 Elsevier Science Ltd. All rights reserved.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30028913

Document type: Journal Article
Collection: School of Medicine
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