Effects of rosiglitazone on intramyocellular lipid accumulation in Psammomys obesus

Molero, Juan Carlos, Lee, Scott, Leizerman, Ilit, Chajut, Ayelet, Cooper, Adrian and Walder, Ken 2010, Effects of rosiglitazone on intramyocellular lipid accumulation in Psammomys obesus, B B A - Molecular Basis of Disease, vol. 1802, no. 2, pp. 235-239.

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Title Effects of rosiglitazone on intramyocellular lipid accumulation in Psammomys obesus
Author(s) Molero, Juan Carlos
Lee, Scott
Leizerman, Ilit
Chajut, Ayelet
Cooper, Adrian
Walder, Ken
Journal name B B A - Molecular Basis of Disease
Volume number 1802
Issue number 2
Start page 235
End page 239
Publisher Elsevier BV
Place of publication Amsterdam, The Netherlands
Publication date 2010-02
ISSN 0925-4439
Keyword(s) Intramyocellular lipid
Rosiglitazone
Thiazolidinedione
Psammomys obesus
Summary Objective: To examine the effects of rosiglitazone in intramyocellular lipid (IMCL) content in diabetic Psammomys obesus using novel electron microscopy technologies.

Background: P. obesus is an unique polygenic model of obesity and type 2 diabetes. Male diabetic P. obesus were treated daily with 5 mg/Kg Rosiglitazone by oral gavage for 14 days. Data were compared with a group of age-matched diabetic P. obesus treated with saline vehicle.

Methods: Assessment of insulin resistance and adiposity were determine before and after the treatment period by oral glucose tolerance test (oGTT) and dual energy X-ray absorptiometry (DEXA) analysis. We used a new scanning electron microscopy technology, (WETSEM) to investigate the effects of rosiglitazone administration on IMCL content, size and distribution in red gastrocnemius muscle.

Results: Rosiglitazone treatment improved glucose tolerance in P. obesus with no difference in the overall body fat content although a significant reduction in subscapular fat mass was observed. Rosiglitazone changed the distribution of lipid droplet size in skeletal muscle. Treated animals tended to have smaller lipid droplets compared with saline-treated controls.

Conclusions: Since smaller IMCL droplets are associated with improvements in insulin sensitivity, we propose that this may be an important mechanism by which rosiglitazone affects glucose tolerance.
Language eng
Field of Research 060602 Animal Physiology - Cell
Socio Economic Objective 920104 Diabetes
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2010, Elsevier B.V.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30029020

Document type: Journal Article
Collections: School of Medicine
Institute for Technology Research and Innovation
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