Boron nitride nanotubes : a novel vector for targeted magnetic drug delivery

Ciofani, Gianni, Raffa, Vittoria, Yu, Jun, Chen, Ying, Obata, Yosuke, Takeoka, Shinji, Menciassi, Arianna and Cuschieri, Alfred 2009, Boron nitride nanotubes : a novel vector for targeted magnetic drug delivery, Current nanoscience, vol. 5, no. 1, pp. 33-38.

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Title Boron nitride nanotubes : a novel vector for targeted magnetic drug delivery
Author(s) Ciofani, Gianni
Raffa, Vittoria
Yu, Jun
Chen, Ying
Obata, Yosuke
Takeoka, Shinji
Menciassi, Arianna
Cuschieri, Alfred
Journal name Current nanoscience
Volume number 5
Issue number 1
Start page 33
End page 38
Total pages 6
Publisher Bentham Science Publishers
Place of publication Bussum, Netherlands
Publication date 2009-02
ISSN 1573-4137
1875-6786
Keyword(s) Boron nitride nanotubes,
magnetism
targeted drug delivery
modelling of uptake kinetics
Summary Whereas several biomedical applications of carbon nanotubes have been proposed, the use of boron nitride nanotubes (BNNTs) in this field has been largely unexplored despite their unique and potentially useful properties. Our group has recently initiated an experimental program aimed at the exploration of the interactions between BNNTs and living cells. In the present paper, we report on the magnetic properties of BNNTs containing Fe catalysts which confirm the feasibility for their use as nanovectors for targeted drug delivery. The magnetisation curves of BNNTs characterised by the present study are typical of superparamagnetic materials with important parameters, including magnetic permeability and magnetic momentum, derived by employing Langevin theory. In-vitro tests have demonstrated the feasibility for influencing the uptake of BNNTs by living cells by exposure to an external magnetic source. A finite element method analysis devised to predict this effect produced predictive data with close agreement with the experimental observations.
Language eng
Field of Research 100703 Nanobiotechnology
Socio Economic Objective 970110 Expanding Knowledge in Technology
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2009, Bentham Science Publisher
Persistent URL http://hdl.handle.net/10536/DRO/DU:30029245

Document type: Journal Article
Collection: Institute for Technology Research and Innovation
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