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Recent advances in nanoneurology for drug delivery to the brain

Kanwar, Jagat R., Kanwar, Rupinder K. and Mahidhara, Ganesh 2009, Recent advances in nanoneurology for drug delivery to the brain, Current nanoscience, vol. 5, no. 4, pp. 441-447.

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Title Recent advances in nanoneurology for drug delivery to the brain
Author(s) Kanwar, Jagat R.
Kanwar, Rupinder K.
Mahidhara, Ganesh
Journal name Current nanoscience
Volume number 5
Issue number 4
Start page 441
End page 447
Total pages 7
Publisher Bentham Science Publishers Ltd.
Place of publication Bussum, Netherlands
Publication date 2009-11
ISSN 1573-4137
1875-6786
Keyword(s) Blood-brain barrier
nanoneurology
neurodegenerative diseases
polymeric nanoparticles and multiple sclerosis
Summary The drug development for neurodegenerative disorders are the major challenge to the science in 21st century. Many FDA approved drugs currently available in the market have limitations in crossing the blood brain barrier (BBB) owing to its complicated vasculature posed by the presence of specialized cells. Nanotechnology is an emerging interdisciplinary area, which have many applications including drug delivery. Nanocarrier drug delivery involves targeting drugs enclosed in a particular polymer and/or amphiphilic lipids. Controlled release, nanoplatform availability for combinatorial therapy and tissue specific targeting by using advanced technologies such as molecular Trojan horse (MTH) technology are the promises of nanotechnology. Different problems are associated with drug delivery
across the BBB. Some are mostly related to the structure of brain microvasculature system while the others are related to the nanomaterial
structure. Different strategies, such as using polymeric/solid lipid nanoparticles and surface modification of nanomaterial with surfactants
like polysorbates have been conducted to solve these limitations. Also, nanodrug formulations with double coatings have been designed for oral delivery of drugs to overcome reticulo-endothelial system and to improve their BBB permeability. It seems that the best choice of strategy and material could be achieved with regard to the physical and chemical structure of the drugs. The present review discusses the potential applications of nanotechnology for drug delivery across the BBB.
Language eng
Field of Research 100709 Nanomedicine
100703 Nanobiotechnology
110903 Central Nervous System
Socio Economic Objective 920112 Neurodegenerative Disorders Related to Ageing
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2009, Bentham Science Publishers Ltd.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30029247

Document type: Journal Article
Collection: Centre for Biotechnology and Interdisciplinary Sciences (BioDeakin)
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Created: Fri, 11 Jun 2010, 12:08:30 EST by Abdullah Al Kafi