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Characterization of high fluid strain micro contractions to study the stress on biological fluids

Tovar-Lopez, Francisco J., Khoshmanesh, Khashayar, Nasabi, M., Rosengarten, Gary and Mitchell, Arnan 2008, Characterization of high fluid strain micro contractions to study the stress on biological fluids, in SPIE 2008 : Progress in biomedical optics and imaging : Proceedings of SPIE Biomedical Applications of Micro- and Nanoengineering IV and Complex Systems conference, SPIE: The International Society for Optical Engineering, Bellingham, WA, pp. 72700H-1-72700H-11.

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Title Characterization of high fluid strain micro contractions to study the stress on biological fluids
Author(s) Tovar-Lopez, Francisco J.
Khoshmanesh, Khashayar
Nasabi, M.
Rosengarten, Gary
Mitchell, Arnan
Conference name Biomedical Applications of Micro- and Nanoengineering IV and Complex Systems. Conference (9th : 2008 : Melbourne, Victoria)
Conference location Melbourne, Victoria
Conference dates 10-12 Dec. 2008
Title of proceedings SPIE 2008 : Progress in biomedical optics and imaging : Proceedings of SPIE Biomedical Applications of Micro- and Nanoengineering IV and Complex Systems conference
Editor(s) [Unknown]
Publication date 2008
Series Proceedings of SPIE ; vol. 2720
Conference series Biomedical Applications of Micro- and Nanoengineering IV and Complex Systems Conference
Start page 72700H-1
End page 72700H-11
Publisher SPIE: The International Society for Optical Engineering
Place of publication Bellingham, WA
Keyword(s) CFD
Extensional flow
Micro fabrication
Micro fluidics
Micro PIV
Summary Microfluidics has the potential to enhance the understanding of the biological fluids under strain, due to the laminar nature of the fluid and the possibility to mimic the real conditions. We present advances on charaterization of a microfluidic platform to study high strain rate flows in the transport of biological fluids. These advances are improvements on the reproduction of a  constant extensional strain rate using micro contractions and development of 3D numerical models. The micro geometries have been fabricated in polydimethyl siloxame (PDMS) using standard soft-lithography techniques with a photolithographically patterned mold. A comparison of some microcontractions with different funnel characteristics is presented. The Micro Particle Image Velocimetry technique has been applied to validate the numerical simulations. We demonstrate the use of microfluidics in the reproduction of a large range of controllable extensional strains that can be used in the study of the effect of flow on biological fluids.
ISSN 1605-7422
Language eng
Field of Research 091306 Microelectromechanical Systems (MEMS)
Socio Economic Objective 861503 Scientific Instruments
HERDC Research category E1.1 Full written paper - refereed
ERA Research output type E Conference publication
HERDC collection year 2008
Copyright notice ©2008, SPIE
Persistent URL http://hdl.handle.net/10536/DRO/DU:30029318

Document type: Conference Paper
Collection: Centre for Intelligent Systems Research
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