Hydrodynamic flow focusing to study the isolated effects of the flow components

Tovar-Lopez, Francisco J., Khoshmanesh, Khashayar, Nasabi, M., Kalantar-zadeh, K., Rosengarten, Gary and Mitchell, Arnan 2008, Hydrodynamic flow focusing to study the isolated effects of the flow components, in SPIE 2008 : Progress in biomedical optics and imaging : Proceedings of SPIE Biomedical Applications of Micro- and Nanoengineering IV and Complex Systems conference, SPIE: The International Society for Optical Engineering, Bellingham, WA, pp. 727000L-1-727000L-10.

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Title Hydrodynamic flow focusing to study the isolated effects of the flow components
Author(s) Tovar-Lopez, Francisco J.
Khoshmanesh, Khashayar
Nasabi, M.
Kalantar-zadeh, K.
Rosengarten, Gary
Mitchell, Arnan
Conference name Biomedical Applications of Micro- and Nanoengineering IV and Complex Systems. Conference (9th : 2008 : Melbourne, Victoria)
Conference location Melbourne, Victoria
Conference dates 10-12 Dec. 2008
Title of proceedings SPIE 2008 : Progress in biomedical optics and imaging : Proceedings of SPIE Biomedical Applications of Micro- and Nanoengineering IV and Complex Systems conference
Editor(s) [Unknown]
Publication date 2008
Series Proceedings of SPIE ; vol. 2720
Conference series Biomedical Applications of Micro- and Nanoengineering IV and Complex Systems Conference
Start page 727000L-1
End page 727000L-10
Publisher SPIE: The International Society for Optical Engineering
Place of publication Bellingham, WA
Keyword(s) Micro fluidics
Micro PIV
CFD
Micro fabrication
Flow focusing
Summary Biological fluids such as blood, proteins and DNA solutiosn moving within fluidic channels can potentially be exposed to high level of shear, extension or mixed stress, either in vitro such as industrial processing of blood products or in vivo such as ocurrs in some pathological conditions. This exposure to a high level of strain can trigger some reactions. In most of the cases the nature of the flow is mixed with shear and extensional components. The ability ot isolate the effects of each component is critical in order to understand the mechanisms behind the reactions and potentially prevent them. Applying hydrodynamic flow focusing, we present in this investigation the characterization of microchannels that allow study of the regions of high shear or high extension strain rate. Micro channels were fabricated in polydimethyl siloxane (PDMS)  using standard soft-lithography techniques with a photolithographically patterned mold. Characterization of the regions with high shear and high extension strain rate is presented. Computational Fluid Dynamics (CFD) simulations in three dimensions have been carried out to gain more detailed local flow information, and the results have been validated experimentally. A comparison between the numerical models and experiment and is presented. The advantages of microfluidic flow focusing in the study  of the effects of shear and extension strain rates for biological fluids are outlined.
ISSN 1605-7422
Language eng
Field of Research 091306 Microelectromechanical Systems (MEMS)
Socio Economic Objective 861503 Scientific Instruments
HERDC Research category E1.1 Full written paper - refereed
ERA Research output type E Conference publication
HERDC collection year 2008
Copyright notice ©2008, SPIE
Persistent URL http://hdl.handle.net/10536/DRO/DU:30029324

Document type: Conference Paper
Collection: Centre for Intelligent Systems Research
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