Precision milled flow-cells for chemiluminescence detection

Mohr, Stephan, Terry, Jessica M., Adcock, Jacqui L., Fielden, Peter R., Goddard, Nick J., Barnett, Neil W., Wolcott, Duane K. and Francis, Paul S. 2009, Precision milled flow-cells for chemiluminescence detection, Analyst, vol. 134, no. 11, pp. 2233-2238, doi: 10.1039/b914595h.

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Title Precision milled flow-cells for chemiluminescence detection
Author(s) Mohr, Stephan
Terry, Jessica M.
Adcock, Jacqui L.ORCID iD for Adcock, Jacqui L.
Fielden, Peter R.
Goddard, Nick J.
Barnett, Neil W.
Wolcott, Duane K.
Francis, Paul S.ORCID iD for Francis, Paul S.
Journal name Analyst
Volume number 134
Issue number 11
Start page 2233
End page 2238
Total pages 6
Publisher Royal Society of Chemistry
Place of publication Cambridge, England
Publication date 2009
ISSN 0003-2654
Summary Novel flow-cells with integrated confluence points and reaction channels designed for efficient mixing of fast chemiluminescence systems were constructed by machining opposing sides of a polymer chip and sealing the channels with transparent epoxy-acetate films. A hole drilled through the chip provided the conduit from the confluence point on one side to the centre of the reaction zone on the other side, allowing rapid presentation of the reacting mixture to the photodetector. The effectiveness of each flow-cell was evaluated by comparing the chemiluminescence intensity using flow injection analysis methodology, and examining the distribution of light emanating from the reaction zone (captured by photography in a dark room) when the reactants were continuously merged. Although previously reported chemiluminescence detectors constructed by machining channels into polymers have almost exclusively been prepared using transparent materials, we obtained far greater emission intensities using an opaque white chip with a thin transparent seal, which minimised the loss of light through surfaces not exposed to the photomultiplier tube. Furthermore, this approach enabled the exploration of reactor designs that could not be incorporated in traditional coiled-tubing flow-cells.
Notes First published as an Advance Article on the web 10th September 2009
Language eng
DOI 10.1039/b914595h
Field of Research 030101 Analytical Spectrometry
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
HERDC collection year 2009
Copyright notice ©2009, Royal Society of Chemistry
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