Docosapentaenoic acid (22:5n-3) : a review of its biological effects

Kaur, Gunveen, Cameron-Smith, David, Garg, Manohar and Sinclair, Andrew J. 2011, Docosapentaenoic acid (22:5n-3) : a review of its biological effects, Progress in lipid research, vol. 50, no. 1, pp. 28-34.

Attached Files
Name Description MIMEType Size Downloads

Title Docosapentaenoic acid (22:5n-3) : a review of its biological effects
Author(s) Kaur, Gunveen
Cameron-Smith, David
Garg, Manohar
Sinclair, Andrew J.
Journal name Progress in lipid research
Volume number 50
Issue number 1
Start page 28
End page 34
Total pages 7
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2011-01
ISSN 0163-7827
1873-2194
Keyword(s) n-3 Polyunsaturated fatty acids (VLCPUFA)
eicosapentaenoic acid (EPA)
docosapentaenoic acid (DPA)
docosahexaenoic acid (DHA)
Summary This article summarizes the current knowledge available on metabolism and the biological effects of n-3 docosapentaenoic acid (DPA). n-3 DPA has not been extensively studied because of the limited availability of the pure compound. n-3 DPA is an elongated metabolite of EPA and is an intermediary product between EPA and DHA. The literature on n-3 DPA is limited, however the available data suggests it has beneficial health effects. In vitro n-3 DPA is retro-converted back to EPA, however it does not appear to be readily metabolised to DHA. In vivo studies have shown limited conversion of n-3 DPA to DHA, mainly in liver, but in addition retro-conversion to EPA is evident in a number of tissues. n-3 DPA can be metabolised by lipoxygenase, in platelets, to form ll-hydroxy-7,9,13,16,19- and 14-hydroxy-7,10,12,16,19-DPA. It has also been reported that n-3 DPA is effective (more so than EPA and DHA) in inhibition of aggregation in platelets obtained from rabbit blood. In addition, there is evidence that n-3 DPA possesses 10-fold greater endothelial cell migration ability than EPA, which is important in wound-healing processes. An in vivo study has reported that n-3 DPA reduces the fatty acid synthase and malic enzyme activity levels in n-3 DPA-supplemented mice and these effects were stronger than the EPA-supplemented mice. Another recent in vivo study has reported that n-3 DPA may have a role in attenuating age-related decrease in spatial learning and long-term potentiation. However, more research remains to be done to further investigate the biological effects of this n-3 VLCPUFA.
Language eng
Field of Research 110101 Medical Biochemistry: Amino Acids and Metabolites
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2010, Elsevier Ltd.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30029845

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
School of Medicine
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 45 times in TR Web of Science
Scopus Citation Count Cited 52 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 386 Abstract Views, 2 File Downloads  -  Detailed Statistics
Created: Fri, 27 Aug 2010, 11:47:16 EST by Leanne Swaneveld

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.