Docosapentaenoic acid (22:5n-3) : a review of its biological effects

Kaur, Gunveen, Cameron-Smith, David, Garg, Manohar and Sinclair, Andrew J. 2011, Docosapentaenoic acid (22:5n-3) : a review of its biological effects, Progress in lipid research, vol. 50, no. 1, pp. 28-34, doi: 10.1016/j.plipres.2010.07.004.

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Title Docosapentaenoic acid (22:5n-3) : a review of its biological effects
Author(s) Kaur, GunveenORCID iD for Kaur, Gunveen
Cameron-Smith, David
Garg, Manohar
Sinclair, Andrew J.
Journal name Progress in lipid research
Volume number 50
Issue number 1
Start page 28
End page 34
Total pages 7
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2011-01
ISSN 0163-7827
Keyword(s) n-3 Polyunsaturated fatty acids (VLCPUFA)
eicosapentaenoic acid (EPA)
docosapentaenoic acid (DPA)
docosahexaenoic acid (DHA)
Summary This article summarizes the current knowledge available on metabolism and the biological effects of n-3 docosapentaenoic acid (DPA). n-3 DPA has not been extensively studied because of the limited availability of the pure compound. n-3 DPA is an elongated metabolite of EPA and is an intermediary product between EPA and DHA. The literature on n-3 DPA is limited, however the available data suggests it has beneficial health effects. In vitro n-3 DPA is retro-converted back to EPA, however it does not appear to be readily metabolised to DHA. In vivo studies have shown limited conversion of n-3 DPA to DHA, mainly in liver, but in addition retro-conversion to EPA is evident in a number of tissues. n-3 DPA can be metabolised by lipoxygenase, in platelets, to form ll-hydroxy-7,9,13,16,19- and 14-hydroxy-7,10,12,16,19-DPA. It has also been reported that n-3 DPA is effective (more so than EPA and DHA) in inhibition of aggregation in platelets obtained from rabbit blood. In addition, there is evidence that n-3 DPA possesses 10-fold greater endothelial cell migration ability than EPA, which is important in wound-healing processes. An in vivo study has reported that n-3 DPA reduces the fatty acid synthase and malic enzyme activity levels in n-3 DPA-supplemented mice and these effects were stronger than the EPA-supplemented mice. Another recent in vivo study has reported that n-3 DPA may have a role in attenuating age-related decrease in spatial learning and long-term potentiation. However, more research remains to be done to further investigate the biological effects of this n-3 VLCPUFA.
Language eng
DOI 10.1016/j.plipres.2010.07.004
Field of Research 110101 Medical Biochemistry: Amino Acids and Metabolites
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2010, Elsevier Ltd.
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