Hypertension induced by ω-3 polyunsaturated fatty acid deficiency is alleviated by α-linolenic acid regardless of dietary source

Begg, Denovan P., Sinclair, Andrew J., Stahl, Lauren A., Premaratna, Shirmila D., Hafandi, Ahmad, Jois, Mark and Weisinger, Richard S. 2010, Hypertension induced by ω-3 polyunsaturated fatty acid deficiency is alleviated by α-linolenic acid regardless of dietary source, Hypertension research, vol. 13, no. 8, pp. 808-813.

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Title Hypertension induced by ω-3 polyunsaturated fatty acid deficiency is alleviated by α-linolenic acid regardless of dietary source
Author(s) Begg, Denovan P.
Sinclair, Andrew J.
Stahl, Lauren A.
Premaratna, Shirmila D.
Hafandi, Ahmad
Jois, Mark
Weisinger, Richard S.
Journal name Hypertension research
Volume number 13
Issue number 8
Start page 808
End page 813
Total pages 6
Publisher Nature Publishing Group
Place of publication London, England
Publication date 2010-08
ISSN 0916-9636
1348-4214
Keyword(s) adiposity
blood pressure
leptin
omega-3
PUFA
Summary Ω-3 polyunsaturated fatty acid deficiency, particularly during the prenatal period, can cause hypertension in later life. This study examined the effect of different sources of α-linolenic acid (canola oil or flaxseed oil) in the prevention of hypertension and other metabolic symptoms induced by an ω-3 fatty acid-deficient diet. Dams were provided one of three experimental diets from 1 week before mating. Diets were either deficient (10% safflower oil-DEF) or sufficient (7% safflower oil+3% flaxseed oil-SUF-F; or 10% canola oil-SUF-C) in ω-3 fatty acids. The male offspring were continued on the maternal diet from weaning for the duration of the study. Body weight, ingestive behaviors, blood pressure, body composition, metabolic rate, plasma leptin and brain fatty acids were all assessed. The DEF animals were hypertensive at 24 weeks of age compared with SUF-F or SUF-C animals; this was not evident at 12 weeks. These results suggest that different sources of ALA are effective in preventing hypertension related to ω-3 fatty acid deficiency. However, there were other marked differences between the DEF and, in particular, the SUF-C phenotype including lowered body weight, adiposity, leptin and food intake in SUF-C animals. SUF-F animals also had lower, but less marked reductions in adiposity and leptin compared with DEF animals. The differences observed between DEF, SUF-F and SUF-C phenotypes indicate that body fat and leptin may be involved in ω-3 fatty acid deficiency hypertension.
Language eng
Field of Research 110101 Medical Biochemistry: Amino Acids and Metabolites
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2010, The Japanese Society of Hypertension
Persistent URL http://hdl.handle.net/10536/DRO/DU:30029849

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
School of Medicine
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