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Sodium appetite in adult rats following ω-3 polyunsaturated fatty acid deficiency in early development

Weisinger, R. S., Armitage, J. A., Chen, N., Begg, D. P., Mathai, M. L., Jayasooriya, A. P., Sinclair, A. J. and Weisinger, H. S. 2010, Sodium appetite in adult rats following ω-3 polyunsaturated fatty acid deficiency in early development, Appetite, vol. 55, no. 3, pp. 393-397.

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Title Sodium appetite in adult rats following ω-3 polyunsaturated fatty acid deficiency in early development
Author(s) Weisinger, R. S.
Armitage, J. A.
Chen, N.
Begg, D. P.
Mathai, M. L.
Jayasooriya, A. P.
Sinclair, A. J.
Weisinger, H. S.
Journal name Appetite
Volume number 55
Issue number 3
Start page 393
End page 397
Publisher Elsevier BV
Place of publication Dordrecht, The Netherlands
Publication date 2010-12
ISSN 0195-6663
1095-8304
Keyword(s) salt appetite
ω-3 fatty acid deficiency
fos
fluid intake
sodium balance
Summary We examined the effect of ω-3 polyunsaturated fatty acid (PUFA) deficiency during development on sodium appetite. Being raised on an ω-3 PUFA deficient diet increased the intake of 0.5 M NaCl following furosemide-induced sodium depletion by 40%. This occurred regardless of the diet they were maintained on later in life, and the increased consumption persisted for 3 days. In a second study, animals were administered furosemide and low-dose captopril. Sodium consumption of deficient raised animals was again higher than that of the control raised. Fos immunoreactivity in brain areas associated with sodium appetite and excretion were not influenced by diet. Our findings indicate that inadequate dietary ω-3 PUFA during development results in an exaggerated sodium appetite later in life.
Language eng
Field of Research 110101 Medical Biochemistry: Amino Acids and Metabolites
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2010, Elsevier Ltd.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30029853

Document type: Journal Article
Collection: School of Medicine
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