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Gender-specific inhibition of platelet aggregation following omega-3 fatty acid supplementation

Phang, M., Sinclair, A. J., Lincz, L. F. and Garg, M. L. 2012, Gender-specific inhibition of platelet aggregation following omega-3 fatty acid supplementation, Nutrition, metabolism & cardiovascular diseases, vol. 22, no. 2, pp. 109-114, doi: 10.1016/j.numecd.2010.04.012.

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Title Gender-specific inhibition of platelet aggregation following omega-3 fatty acid supplementation
Author(s) Phang, M.
Sinclair, A. J.
Lincz, L. F.
Garg, M. L.
Journal name Nutrition, metabolism & cardiovascular diseases
Volume number 22
Issue number 2
Start page 109
End page 114
Total pages 6
Publisher Medikal Press S.L.R.
Place of publication Napoli, Italy
Publication date 2012-02
ISSN 0939-4753
Keyword(s) docosahexaenoic acid
eicosapentaenoic acid
platelet aggregation
sex hormones
Summary Background and Aims : Increased platelet aggregation is a major risk factor for heart attacks, stroke and thrombosis. Long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA; eicosapentaenoic acid, EPA; docosahexaenoic acid, DHA) reduce platelet aggregation; however studies in the published literature involving EPA and/or DHA supplementation have yielded equivocal results. Recent in vitro studies have demonstrated that inhibition of platelet aggregation by LCn-3PUFA is gender specific. We examined the acute effects of dietary supplementation with EPA or DHA rich oils on platelet aggregation in healthy male and females.

Methods and Results :
A blinded placebo controlled trial involving 15 male and 15 female subjects. Platelet aggregation was measured at 0, 2, 5 and 24 h post-supplementation with a single dose of either a placebo or EPA or DHA rich oil capsules. The relationship between LCn-3PUFA and platelet activity at each time point was examined according to gender vs. treatment. EPA was significantly the most effective in reducing platelet aggregation in males at 2, 5 and 24 h post-supplementation (−11%, −10.6%, −20.5% respectively) whereas DHA was not effective relative to placebo. In contrast, in females, DHA significantly reduced platelet aggregation at 24 h (−13.7%) while EPA was not effective. An inverse relationship between testosterone levels and platelet aggregation following EPA supplementation was observed.

Conclusion : Interactions between sex hormones and omega-3 fatty acids exist to differentially reduce platelet aggregation. For healthy individuals, males may benefit more from EPA supplementation while females are more responsive to DHA.
Language eng
DOI 10.1016/j.numecd.2010.04.012
Field of Research 110101 Medical Biochemistry: Amino Acids and Metabolites
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2010, Elsevier B.V.
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Document type: Journal Article
Collection: School of Medicine
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Created: Fri, 27 Aug 2010, 14:18:48 EST by Leanne Swaneveld

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