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Biomimetic modification of porous TiNbZr alloy scaffold for bone tissue engineering

Wang, Xiaojian, Li, Yuncang, Hodgson, Peter and Wen, Cui'e 2010, Biomimetic modification of porous TiNbZr alloy scaffold for bone tissue engineering, Tissue engineering : part A, vol. 16, no. 1, pp. 309-316, doi: 10.1089/ten.tea.2009.0074.

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Title Biomimetic modification of porous TiNbZr alloy scaffold for bone tissue engineering
Author(s) Wang, Xiaojian
Li, Yuncang
Hodgson, Peter
Wen, Cui'e
Journal name Tissue engineering : part A
Volume number 16
Issue number 1
Start page 309
End page 316
Total pages 8
Publisher Mary Ann Liebert Publishers
Place of publication New Rochelle, N.Y.
Publication date 2010-01-08
ISSN 1937-3341
1937-335X
Summary Porous titanium (Ti) and Ti alloys are important scaffold materials for bone tissue engineering. In the present study, a new type of porous Ti alloy scaffold with biocompatible alloying elements, that is, niobium (Nb) and zirconium (Zr), was prepared by a space-holder sintering method. This porous TiNbZr scaffold with a porosity of 69% exhibits a mechanical strength of 67MPa and an elastic modulus of 3.9GPa, resembling the mechanical properties of cortical bone. To improve the osteoconductivity, a calcium phosphate (Ca/P) coating was applied to the surface of the scaffold using a biomimetic method. The biocompatibility of the porous TiNbZr alloy scaffold before and after the biomimetic modification was assessed using the SaOS2 osteoblast–like cells. Cell culture results indicated that the porous TiNbZr scaffold is more favorable for cell adhesion and proliferation than its solid counterpart. By applying a Ca/P coating, the cell proliferation rate on the Ca/P-coated scaffold was significantly improved. The results suggest that high-strength porous TiNbZr scaffolds with an appropriate osteoconductive coating could be potentially used for bone tissue engineering application.
Notes Online Publication Date: September 28, 2009
Language eng
DOI 10.1089/ten.tea.2009.0074
Field of Research 090301 Biomaterials
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2010
Copyright notice ©2010, Mary Ann Liebert Publishers
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30030447

Document type: Journal Article
Collections: Centre for Material and Fibre Innovation
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Created: Mon, 11 Oct 2010, 16:18:43 EST by Sandra Dunoon

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.