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Cytotoxicity of titanium and titanium alloying elements

Li, Yuncang, Wong, Cynthia, Xiong, Jianyu, Hodgson, Peter and Wen, Cui'e 2010, Cytotoxicity of titanium and titanium alloying elements, Journal of dental research, vol. 89, no. 5, pp. 493-497, doi: 10.1177/0022034510363675.

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Title Cytotoxicity of titanium and titanium alloying elements
Author(s) Li, Yuncang
Wong, Cynthia
Xiong, Jianyu
Hodgson, Peter
Wen, Cui'e
Journal name Journal of dental research
Volume number 89
Issue number 5
Start page 493
End page 497
Total pages 5
Publisher Sage Publications, Inc
Place of publication Thousand Oaks, Calif.
Publication date 2010-05
ISSN 0022-0345
1544-0591
Keyword(s) cytotoxicity
titanium
titanium alloy elements
metal powder
Summary It is commonly accepted that titanium and the titanium alloying elements of tantalum, niobium, zirconium, molybdenum, tin, and silicon are biocompatible. However, our research in the development of new titanium alloys for biomedical applications indicated that some titanium alloys containing molybdenum, niobium, and silicon produced by powder metallurgy show a certain degree of cytotoxicity. We hypothesized that the cytotoxicity is linked to the ion release from the metals. To prove this hypothesis, we assessed the cytotoxicity of titanium and titanium alloying elements in both forms of powder and bulk, using osteoblast-like SaOS2 cells. Results indicated that the metal powders of titanium, niobium, molybdenum, and silicon are cytotoxic, and the bulk metals of silicon and molybdenum also showed cytotoxicity. Meanwhile, we established that the safe ion concentrations (below which the ion concentration is non-toxic) are 8.5, 15.5, 172.0, and 37,000.0 μg/L for molybdenum, titanium, niobium, and silicon, respectively.
Notes Published online before print March 23, 2010
Language eng
DOI 10.1177/0022034510363675
Field of Research 090301 Biomaterials
Socio Economic Objective 861299 Fabricated Metal Products not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2010
Copyright notice ©2010, by International & American Associations for Dental Research
Persistent URL http://hdl.handle.net/10536/DRO/DU:30030448

Document type: Journal Article
Collection: Centre for Material and Fibre Innovation
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Created: Mon, 11 Oct 2010, 16:49:53 EST by Sandra Dunoon

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