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Mitrochondrial target discovery in diabetic skeletal muscle

Kerr-Bayles, Lyndal 2009, Mitrochondrial target discovery in diabetic skeletal muscle, Ph.D. thesis, School of Medicine, Deakin University.


Title Mitrochondrial target discovery in diabetic skeletal muscle
Author Kerr-Bayles, Lyndal
Institution Deakin University
School School of Medicine
Faculty Faculty of Health, Medicine, Nursing and Behavioural Sciences
Degree name Ph.D.
Date submitted 2009
Keyword(s) Striated muscle - Genetic aspects
Gene expression
Non-insulin-dependent diabetes - Genetic aspects
Mitochondria - Genetic aspects
Mitochondrial pathology
Summary This study identified the protein PARL (Presenilin-associated rhomboid like) as a potential mediator of the mitochondrial abnormalities that are observed in diabetic skeletal muscle. This was demonstrated by analysing PARL expression in an animal model of type 2 diabetes and by investigating the biological effects of genetic variation in the human PARL gene.
Notes Degree conferred 2010.
Language eng
Description of original xiv, 279 leaves ; 30 cm.
Dewey Decimal Classification 611.0186
Persistent URL http://hdl.handle.net/10536/DRO/DU:30030549

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Created: Fri, 15 Oct 2010, 14:11:44 EST

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