Post-prandial remnant lipids impair arterial compliance

Nestel, Paul J., Shige, Hideki, Pomeroy, Sylvia, Cehun, Marja and Chin-Dusting, Jaye 2001, Post-prandial remnant lipids impair arterial compliance, Journal of the American College of Cardiology, vol. 37, no. 7, pp. 1929-1935, doi: 10.1016/S0735-1097(01)01251-7.

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Title Post-prandial remnant lipids impair arterial compliance
Author(s) Nestel, Paul J.
Shige, Hideki
Pomeroy, Sylvia
Cehun, Marja
Chin-Dusting, Jaye
Journal name Journal of the American College of Cardiology
Volume number 37
Issue number 7
Start page 1929
End page 1935
Publisher Elsevier Inc.
Place of publication San Diego, Calif.
Publication date 2001-06-01
ISSN 0735-1097
We sought to examine the effects of plasma lipids, especially in remnants after a fat meal, on systemic arterial compliance (SAC), a newly recognized cardiovascular risk factor.
Post-prandial remnants correlate with coronary heart disease events through mechanisms that may include vascular dysfunction, although the effect on SAC has not been studied.
Systemic arterial compliance was measured non-invasively over 6 h after a fat meal in 16 subjects with varying plasma triglyceride levels. Changes were related to rises in plasma lipids and remnant lipids. Systemic arterial compliance was measured in 20 subjects after a control low-fat meal.
The fat meal induced increments in plasma triglyceride and remnant cholesterol and triglyceride (respectively +54%, 50% and 290% at 3 h, analysis of variance <0.001). Systemic arterial compliance fell at 3 h and 6 h by 25% and 27% (analysis of variance <0.001). Baseline SAC correlated significantly with all lipid concentrations at 0, 3 h and 6 h, but only with triglyceride on stepwise regression analysis. The SAC response to the low-fat meal was very small and not significant.
This is the first demonstration of SAC becoming impaired after a fat meal. Remnant lipids and plasma total triglyceride appeared to contribute to the fall in SAC.
Language eng
DOI 10.1016/S0735-1097(01)01251-7
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2001, American College of Cardiology
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Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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