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Post-prandial remnant lipids impair arterial compliance

Nestel, Paul J., Shige, Hideki, Pomeroy, Sylvia, Cehun, Marja and Chin-Dusting, Jaye 2001, Post-prandial remnant lipids impair arterial compliance, Journal of the American College of Cardiology, vol. 37, no. 7, pp. 1929-1935, doi: 10.1016/S0735-1097(01)01251-7.

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Title Post-prandial remnant lipids impair arterial compliance
Author(s) Nestel, Paul J.
Shige, Hideki
Pomeroy, Sylvia
Cehun, Marja
Chin-Dusting, Jaye
Journal name Journal of the American College of Cardiology
Volume number 37
Issue number 7
Start page 1929
End page 1935
Publisher Elsevier Inc.
Place of publication San Diego, Calif.
Publication date 2001-06-01
ISSN 0735-1097
1558-3597
Summary OBJECTIVES
We sought to examine the effects of plasma lipids, especially in remnants after a fat meal, on systemic arterial compliance (SAC), a newly recognized cardiovascular risk factor.
BACKGROUND
Post-prandial remnants correlate with coronary heart disease events through mechanisms that may include vascular dysfunction, although the effect on SAC has not been studied.
METHODS
Systemic arterial compliance was measured non-invasively over 6 h after a fat meal in 16 subjects with varying plasma triglyceride levels. Changes were related to rises in plasma lipids and remnant lipids. Systemic arterial compliance was measured in 20 subjects after a control low-fat meal.
RESULTS
The fat meal induced increments in plasma triglyceride and remnant cholesterol and triglyceride (respectively +54%, 50% and 290% at 3 h, analysis of variance <0.001). Systemic arterial compliance fell at 3 h and 6 h by 25% and 27% (analysis of variance <0.001). Baseline SAC correlated significantly with all lipid concentrations at 0, 3 h and 6 h, but only with triglyceride on stepwise regression analysis. The SAC response to the low-fat meal was very small and not significant.
CONCLUSIONS
This is the first demonstration of SAC becoming impaired after a fat meal. Remnant lipids and plasma total triglyceride appeared to contribute to the fall in SAC.
Language eng
DOI 10.1016/S0735-1097(01)01251-7
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2001, American College of Cardiology
Persistent URL http://hdl.handle.net/10536/DRO/DU:30030888

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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