Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women

Nestel, Paul J., Pomeroy, Sylvia, Kay, Sally, Komesaroff, Paul, Behrsing, Julie, Cameron, James D. and West, Leanne 1999, Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women, Journal of clinical endocrinology & metabolism, vol. 84, no. 3, pp. 895-898.

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Title Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women
Author(s) Nestel, Paul J.
Pomeroy, Sylvia
Kay, Sally
Komesaroff, Paul
Behrsing, Julie
Cameron, James D.
West, Leanne
Journal name Journal of clinical endocrinology & metabolism
Volume number 84
Issue number 3
Start page 895
End page 898
Publisher The Endocrine Society
Place of publication Philadelphia, PA
Publication date 1999-03
ISSN 0021-972X
Summary The possibility that the heightened cardiovascular risk associated with the menopause can be reduced by increasing dietary isoflavone intake was tested in 17 women by measuring arterial compliance, an index of the elasticity of large arteries such as the thoracic aorta. Compliance diminishes with age and menopause. An initial 3- to 4-week run-in period and a 5-week placebo period were followed by two 5-week periods of active treatment with 40 mg and then 80 mg isoflavones derived from red clover containing genistein, daidzein, biochanin, and formononetin in 14 and 13 women, respectively, with 3 others serving as placebo controls throughout. Arterial compliance, measured by ultrasound as a pressure (carotid artery) and volume (outflow into aorta) relationship, was determined after each period; plasma lipids were measured twice during each period. Urinary output of isoflavones was also determined. Arterial compliance rose by 23% relative to that during the placebo period with the 80-mg isoflavone dose and slightly less with the 40-mg dose (mean6SEM: placebo, 19.761.5; 40 mg, 23.760.7; 80 mg, 24.46 1.4). In the three women receiving continuous placebo, compliance was 16 6 2.2, similar to that during the run-in period for the remaining subjects (17 6 2.1). ANOVA showed a significant (P 5 , 0.001) difference between treatments; by Bonferroni multiple comparisons and by paired t test, differences were significant between placebo and 40- and 80-mg isoflavone doses (by paired t test: P50.039 for placebo vs. 40 mg; P 5 0.018 for placebo vs. 80 mg). Plasma lipids were not significantly affected. An important cardiovascular risk factor, arterial compliance, which diminishes with menopause, was significantly improved with red clover isoflavones. As diminished compliance leads to systolic hypertension and may increase left ventricular work, the findings indicate a potential new therapeutic approach for improved cardiovascular function after menopause.
Language eng
Field of Research 110199 Medical Biochemistry and Metabolomics not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©1999, The Endocrine Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30030890

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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