Arterial compliance in obese subjects is improved with dietary plant n-3 fatty acid from flaxseed oil despite increased LDL oxidizability

Nestel, Paul J., Pomeroy, Sylvia, Sasahara, Takayuki, Yamashita, Takeshi, Liang, Yu Lu, Dart, Anthony M., Jennings, Garry L., Abbey, Mavis and Cameron, James D. 1997, Arterial compliance in obese subjects is improved with dietary plant n-3 fatty acid from flaxseed oil despite increased LDL oxidizability, Arteriosclerosis, thrombosis, and vascular biology, vol. 17, no. 6, pp. 1163-1170.

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Title Arterial compliance in obese subjects is improved with dietary plant n-3 fatty acid from flaxseed oil despite increased LDL oxidizability
Author(s) Nestel, Paul J.
Pomeroy, Sylvia
Sasahara, Takayuki
Yamashita, Takeshi
Liang, Yu Lu
Dart, Anthony M.
Jennings, Garry L.
Abbey, Mavis
Cameron, James D.
Journal name Arteriosclerosis, thrombosis, and vascular biology
Volume number 17
Issue number 6
Start page 1163
End page 1170
Publisher Lippincott Williams & Wilkins
Place of publication Philadelphia, Pa.
Publication date 1997-06
ISSN 1079-5642
Summary The compliance or elasticity of the arterial system, an important index of circulatory function, diminishes with increasing cardiovascular risk. Conversely, systemic arterial compliance improves through eating of fish and fish oil. We therefore tested the value of high intake of alpha-linolenic acid, the plant precursor of fish fatty acids. Fifteen obese people with markers for insulin resistance ate in turn four diets of 4 weeks each: saturated/high fat (SHF), alpha-linolenic acid/low fat (ALF), oleic/low fat (OLF), and SHF. Daily intake of alpha-linolenic acid was 20 g from margarine products based on flax oil. Systemic arterial compliance was calculated from aortic flow velocity and aortic root driving pressure. Plasma lipids, glucose tolerance, and in vitro LDL oxidizability were also measured. Systemic arterial compliance during the first and last SHF periods was 0.42 +/- 0.12 (mean +/- SD) and 0.56 +/- 0.21 units based on milliliters per millimeter of mercury. It rose significantly to 0.78 +/- 0.28 (P < .0001) with ALF; systemic arterial compliance with OLF was 0.62 +/- 0.19, lower than with ALF (P < .05). Mean arterial pressures and results of oral glucose tolerance tests were similar during ALF, OLF, and second SHF; total cholesterol levels were also not significantly different. However, insulin sensitivity and HDL cholesterol diminished and LDL oxidizability increased with ALF. The marked rise in arterial compliance at least with alpha-linolenic acid reflected rapid functional improvement in the systemic arterial circulation despite a rise in LDL oxidizability. Dietary n-3 fatty acids in flax oil thus confer a novel approach to improving arterial function.
Language eng
Field of Research 110199 Medical Biochemistry and Metabolomics not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©1997, American Heart Association, Inc.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30030891

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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