Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women
Nestel, Paul J., Yamashita, Takeshi, Sasahara, Takayuki, Pomeroy, Sylvia, Dart, Anthony, Komesaroff, Paul, Owen, Alice and Abbey, Mavis 1997, Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women, Arteriosclerosis, thrombosis, and vascular biology, vol. 17, no. 12, pp. 3392-3398.
Attached Files
Name
Description
MIMEType
Size
Downloads
Title
Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women
Arteriosclerosis, thrombosis, and vascular biology
Volume number
17
Issue number
12
Start page
3392
End page
3398
Publisher
Lippincott Williams & Wilkins
Place of publication
Philadelphia, Pa.
Publication date
1997-12
ISSN
1079-5642
Summary
The possibility that the heightened cardiovascular risk associated with the menopause, which is said to be ameliorated by soybeans, can be reduced with soy isoflavones was tested in 21 women. Although several were perimenopausal, all have been included. A placebo-controlled crossover trial tested the effects of 80-mg daily isoflavones (45 mg genistein) over 5- to 10-week periods. Systemic arterial compliance (arterial elasticity), which declined with age in this group, improved 26% (P < .001) compared with placebo. Arterial pressure and plasma lipids were unaffected. The vasodilatory capacity of the microcirculation was measured in nine women; high acetylcholine-mediated dilation in the forearm vasculature was similar with active and placebo treatments. LDL oxidizability measured in vitro was unchanged. Thus, one important measure of arterial health, systemic arterial compliance, was significantly improved in perimenopausal and menopausal women taking soy isoflavones to about the same extent as is achieved with conventional hormone replacement therapy.
Language
eng
Field of Research
110199 Medical Biochemistry and Metabolomics not elsewhere classified
Socio Economic Objective
970111 Expanding Knowledge in the Medical and Health Sciences
Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.