Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women Nestel, Paul J., Yamashita, Takeshi, Sasahara, Takayuki, Pomeroy, Sylvia, Dart, Anthony, Komesaroff, Paul, Owen, Alice and Abbey, Mavis 1997, Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women, Arteriosclerosis, thrombosis, and vascular biology, vol. 17, no. 12, pp. 3392-3398. Attached Files Name Description MIMEType Size Downloads Title Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women Author(s) Nestel, Paul J. Yamashita, Takeshi Sasahara, Takayuki Pomeroy, Sylvia Dart, Anthony Komesaroff, Paul Owen, Alice Abbey, Mavis Journal name Arteriosclerosis, thrombosis, and vascular biology Volume number 17 Issue number 12 Start page 3392 End page 3398 Publisher Lippincott Williams & Wilkins Place of publication Philadelphia, Pa. Publication date 1997-12 ISSN 1079-5642 Summary The possibility that the heightened cardiovascular risk associated with the menopause, which is said to be ameliorated by soybeans, can be reduced with soy isoflavones was tested in 21 women. Although several were perimenopausal, all have been included. A placebo-controlled crossover trial tested the effects of 80-mg daily isoflavones (45 mg genistein) over 5- to 10-week periods. Systemic arterial compliance (arterial elasticity), which declined with age in this group, improved 26% (P < .001) compared with placebo. Arterial pressure and plasma lipids were unaffected. The vasodilatory capacity of the microcirculation was measured in nine women; high acetylcholine-mediated dilation in the forearm vasculature was similar with active and placebo treatments. LDL oxidizability measured in vitro was unchanged. Thus, one important measure of arterial health, systemic arterial compliance, was significantly improved in perimenopausal and menopausal women taking soy isoflavones to about the same extent as is achieved with conventional hormone replacement therapy. Language eng Field of Research 110199 Medical Biochemistry and Metabolomics not elsewhere classified Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1.1 Refereed article in a scholarly journal Copyright notice ©1997, American Heart Association, Inc. Persistent URL http://hdl.handle.net/10536/DRO/DU:30030892 Document type: Journal Article Collection: School of Exercise and Nutrition Sciences Related Links Link Description Connect to published version (Restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Wed, 20 Oct 2010, 09:36:36 EST Mon, 20 Dec 2010, 13:52:44 EST Mon, 20 Dec 2010, 13:54:48 EST Wed, 19 Jan 2011, 15:07:33 EST Wed, 19 Jan 2011, 15:09:48 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 0 times in Scopus Search Google Scholar Access Statistics: 333 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Wed, 20 Oct 2010, 09:36:36 EST

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