Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women

Nestel, Paul J., Yamashita, Takeshi, Sasahara, Takayuki, Pomeroy, Sylvia, Dart, Anthony, Komesaroff, Paul, Owen, Alice and Abbey, Mavis 1997, Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women, Arteriosclerosis, thrombosis, and vascular biology, vol. 17, no. 12, pp. 3392-3398.

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Title Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women
Author(s) Nestel, Paul J.
Yamashita, Takeshi
Sasahara, Takayuki
Pomeroy, Sylvia
Dart, Anthony
Komesaroff, Paul
Owen, Alice
Abbey, Mavis
Journal name Arteriosclerosis, thrombosis, and vascular biology
Volume number 17
Issue number 12
Start page 3392
End page 3398
Publisher Lippincott Williams & Wilkins
Place of publication Philadelphia, Pa.
Publication date 1997-12
ISSN 1079-5642
Summary The possibility that the heightened cardiovascular risk associated with the menopause, which is said to be ameliorated by soybeans, can be reduced with soy isoflavones was tested in 21 women. Although several were perimenopausal, all have been included. A placebo-controlled crossover trial tested the effects of 80-mg daily isoflavones (45 mg genistein) over 5- to 10-week periods. Systemic arterial compliance (arterial elasticity), which declined with age in this group, improved 26% (P < .001) compared with placebo. Arterial pressure and plasma lipids were unaffected. The vasodilatory capacity of the microcirculation was measured in nine women; high acetylcholine-mediated dilation in the forearm vasculature was similar with active and placebo treatments. LDL oxidizability measured in vitro was unchanged. Thus, one important measure of arterial health, systemic arterial compliance, was significantly improved in perimenopausal and menopausal women taking soy isoflavones to about the same extent as is achieved with conventional hormone replacement therapy.
Language eng
Field of Research 110199 Medical Biochemistry and Metabolomics not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©1997, American Heart Association, Inc.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30030892

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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