Simultaneous incorporation of 5-fluorouracil and leucovorin into chitosan nanoparticle as drug carrier and its characterization

Li, Puwang, Wang, Yichao, Peng, Zheng and Kong, Lingxue 2010, Simultaneous incorporation of 5-fluorouracil and leucovorin into chitosan nanoparticle as drug carrier and its characterization, Materials science forum, vol. 654-656, pp. 2265-2268.

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Title Simultaneous incorporation of 5-fluorouracil and leucovorin into chitosan nanoparticle as drug carrier and its characterization
Author(s) Li, Puwang
Wang, Yichao
Peng, Zheng
Kong, Lingxue
Journal name Materials science forum
Volume number 654-656
Start page 2265
End page 2268
Total pages 4
Publisher Trans Tech Publications
Place of publication Stafa-Zurich, Switzerland
Publication date 2010-06-30
ISSN 0255-5476
Keyword(s) colorectal cancer
combined therapy
5-fluorouracil
leucovorin
chitosan nanparticles
Summary A combined drug loaded system containing two most common anti-cancer drugs 5-fluorouracil (5-FU) and leucovorin (LV) was designed and prepared by ion crosslinking technology. The resulted nanoparticles are spherical in shape, and the particle size becomes larger when drug combination are loaded. Efficient drug encapsulation efficiency (EE) and drug loading (LC) are obtained due to the strong interaction between drugs and polymer. The combined drugs are distributed in the particles in amorpholous state which are demonstrated by the XRD results.
Language eng
Field of Research 030302 Nanochemistry and Supramolecular Chemistry
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2010
Copyright notice ©2010, Trans Tech Publications
Persistent URL http://hdl.handle.net/10536/DRO/DU:30030944

Document type: Journal Article
Collection: Centre for Material and Fibre Innovation
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