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Dielectrophoretic-activated cell sorter based on curved microelectrodes

Khoshmanesh, Khashayar, Zhang, Chen, Tovar-Lopez, Francisco J., Nahavandi, Saeid, Baratchi, Sara, Mitchell, Arnan and Kalantar-Zadeh, Kourosh 2010, Dielectrophoretic-activated cell sorter based on curved microelectrodes, Microfluidics and nanofluidics, vol. 9, no. 2-3, pp. 411-426.

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Title Dielectrophoretic-activated cell sorter based on curved microelectrodes
Author(s) Khoshmanesh, Khashayar
Zhang, Chen
Tovar-Lopez, Francisco J.
Nahavandi, Saeid
Baratchi, Sara
Mitchell, Arnan
Kalantar-Zadeh, Kourosh
Journal name Microfluidics and nanofluidics
Volume number 9
Issue number 2-3
Start page 411
End page 426
Total pages 16
Publisher Springer
Place of publication Heidelberg, Germany
Publication date 2010-08
ISSN 1613-4982
1613-4990
Keyword(s) dielectrophoresis
microfluidics
yeast
sorting
Summary This article presents the numerical and experimental analysis of a dielectrophoretic-activated cell sorter (DACS), which is equipped with curved microelectrodes. Curved microelectrodes offer unique advantages, since they create strong dielectrophoretic (DEP) forces over the tips and maintain it over a large portion of their structure, as predicted by simulations. The performance of the system is assessed using yeast (Saccharomyces cerevisiae) cells as model organisms. The separation of the live and dead cells is demonstrated at different medium conductivities of 0.001 and 0.14 S/m, and the sorting performance was assessed using a second array of microelectrodes patterned downstream the microchannel. Further, microscopic cell counting analysis reveals that a single pass through the system yields a separating efficiency of ~80% at low medium conductivities and ~85% at high medium conductivities.
Notes Published online: 29 December 2009
Language eng
Field of Research 091306 Microelectromechanical Systems (MEMS)
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2010
Copyright notice ©2009, Springer-Verlag
Persistent URL http://hdl.handle.net/10536/DRO/DU:30031091

Document type: Journal Article
Collections: Institute of Biotechnology
Centre for Intelligent Systems Research
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