Overcoming diversity with a multi-envelope HIV vaccine

Zirkel, A., Brown, B., Jones, B., Sealy, B., Coleclough, C., Stambas, J., Hurwitz, J. L., Slobod, K. S., Bonsignor, M., Doherty, P. C., Freiden, P., Surman, S., Brown, S. A., Lockey, T. D. and Zhan, X. 2004, Overcoming diversity with a multi-envelope HIV vaccine, Current topics in virology, vol. 4.


Title Overcoming diversity with a multi-envelope HIV vaccine
Author(s) Zirkel, A.
Brown, B.
Jones, B.
Sealy, B.
Coleclough, C.
Stambas, J.
Hurwitz, J. L.
Slobod, K. S.
Bonsignor, M.
Doherty, P. C.
Freiden, P.
Surman, S.
Brown, S. A.
Lockey, T. D.
Zhan, X.
Journal name Current topics in virology
Volume number 4
Publisher Research Trends
Place of publication [India]
Publication date 2004
ISSN 0972-4591
Summary A central obstacle to the design of a global HIV vaccine is viral diversity. Antigenic differences in envelope proteins result in distinct HIV serotypes, operationally defined such that antibodies raised against envelope from one serotype will not bind envelope molecules from a different serotype. The existence of serotypes has presented a similar challenge to vaccine development against other pathogens. In such cases, antigenic diversity has been addressed by vaccine design: for example, the poliovirus vaccine includes 3 serotypes of poliovirus, and Pneumovax® presents a cocktail of 23 pneumococcal variants to the immune system. It is likely that a successful vaccine for HIV must also comprise a cocktail of antigens. Here, data relevant to the development of cocktail vaccines, designed to harness diverse, envelope-specific B-cell and T-cell responses, are reviewed.
Language eng
Field of Research 110704 Cellular Immunology
Socio Economic Objective 920109 Infectious Diseases
HERDC Research category C3.1 Non-refereed articles in a professional journal
Copyright notice ©2005, Research Trends
Persistent URL http://hdl.handle.net/10536/DRO/DU:30031117

Document type: Journal Article
Collection: School of Medicine
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