Preliminary results of the application of a silk fibroin scaffold to otology

Levin, Brett, Redmond, Sharon Leanne, Rajkhowa, Rangam, Eikelboom, Robert Henry, Marano, Robert Jeffery and Atlas, Marcus David 2010, Preliminary results of the application of a silk fibroin scaffold to otology, Otolaryngology–head and neck surgery, vol. 142, no. 3, Supplement 1, pp. S33-S35, doi: 10.1016/j.otohns.2009.06.746.

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Title Preliminary results of the application of a silk fibroin scaffold to otology
Author(s) Levin, Brett
Redmond, Sharon Leanne
Rajkhowa, RangamORCID iD for Rajkhowa, Rangam
Eikelboom, Robert Henry
Marano, Robert Jeffery
Atlas, Marcus David
Journal name Otolaryngology–head and neck surgery
Volume number 142
Issue number 3
Season Supplement 1
Start page S33
End page S35
Total pages 3
Publisher Mosby, Inc.
Place of publication Philadelphia, Pa.
Publication date 2010-03
ISSN 0194-5998
Summary The surgical treatment to repair chronic tympanic membrane perforations is myringoplasty. Although multiple autologous grafts, allografts, and synthetic graft materials have been used over the years, no single graft material is superior for repairing all perforation types. Recently, the remarkable properties of silk fibroin protein have been studied, with biomedical and tissue engineering applications in mind, across a number of medical and surgical disciplines. The present study examines the use of silk fibroin for its potential suitability as an alternative graft in myringoplasty surgery by investigating the growth and proliferation of human tympanic membrane keratinocytes on a silk fibroin scaffold in vitro. Light microscopy, immunofluorescent staining, and confocal imaging all reveal promising preliminary results. The biocompatibility, transparency, stability, high tensile strength, and biodegradability of fibroin make this biomaterial an attractive option to study for this utility.
Language eng
DOI 10.1016/j.otohns.2009.06.746
Field of Research 111299 Oncology and Carcinogenesis not elsewhere classified
Socio Economic Objective 920107 Hearing, Vision, Speech and Their Disorders
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2010
Copyright notice ©2010, American Academy of Otolaryngology–Head and Neck Surgery Foundation. All rights reserved.
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